|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: D-galacturonate degradation II
Supersedes EC number: 22.214.171.124
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: uronate dehydrogenase
Enzyme Commission Synonyms: uronate: NAD-oxidoreductase, uronic acid dehydrogenase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -4.6782227 [Latendresse13]
Enzyme Commission Summary:
Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum C58, participates in oxidative degradation pathways for galacturonate and glucuronate. The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate.
Andberg12: Andberg M, Maaheimo H, Boer H, Penttila M, Koivula A, Richard P (2012). "Characterization of a novel Agrobacterium tumefaciens galactarolactone cycloisomerase enzyme for direct conversion of D-galactarolactone to 3-deoxy-2-keto-L-threo-hexarate." J Biol Chem 287(21);17662-71. PMID: 22493433
Boer10: Boer H, Maaheimo H, Koivula A, Penttila M, Richard P (2010). "Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene." Appl Microbiol Biotechnol 86(3);901-9. PMID: 19921179
©2014 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493