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MetaCyc Reaction: 1.1.1.203

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.203

Enzymes and Genes:

Agrobacterium fabrum C58 : uronate dehydrogenase Inferred from experiment : udh
Pseudomonas syringae : uronate dehydrogenase Inferred from experiment : udh

In Pathway: D-galacturonate degradation II

Supersedes EC number: 1.2.1.35

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: uronate dehydrogenase

Enzyme Commission Synonyms: uronate: NAD-oxidoreductase, uronic acid dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.6782227 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+. The enzyme, characterized from the bacterium Agrobacterium fabrum C58, participates in oxidative degradation pathways for galacturonate and glucuronate. The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyse spontaneously at a substantial rate.

Citations: [Andberg12, Kilgore59, Boer10]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01981 , Rhea:22404

Relationship Links: BRENDA:EC:1.1.1.203 , ENZYME:EC:1.1.1.203 , IUBMB-ExplorEnz:EC:1.1.1.203

Credits:
Created 26-Sep-2014 by Caspi R , SRI International


References

Andberg12: Andberg M, Maaheimo H, Boer H, Penttila M, Koivula A, Richard P (2012). "Characterization of a novel Agrobacterium tumefaciens galactarolactone cycloisomerase enzyme for direct conversion of D-galactarolactone to 3-deoxy-2-keto-L-threo-hexarate." J Biol Chem 287(21);17662-71. PMID: 22493433

Boer10: Boer H, Maaheimo H, Koivula A, Penttila M, Richard P (2010). "Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene." Appl Microbiol Biotechnol 86(3);901-9. PMID: 19921179

Kilgore59: Kilgore WW, Starr MP (1959). "Uronate oxidation by phytopathogenic pseudomonads." Nature 183(4672);1412-3. PMID: 13657147

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Apr 18, 2015, biocyc11.