Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.99.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.99.2

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tyrosine phenol-lyase

Enzyme Commission Synonyms: β-tyrosinase, L-tyrosine phenol-lyase (deaminating)

Sub-reactions:
L-tyrosine = phenol + 2-aminoprop-2-enoate + H+ ,
2-aminoprop-2-enoate → 2-iminopropanoate ,
2-iminopropanoate + H+ + H2O → pyruvate + ammonium

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.35287666 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme also slowly catalyses pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.

Citations: [Kumagai70, Kumagai70a]

Unification Links: KEGG:R00728 , Rhea:21707

Relationship Links: BRENDA:EC:4.1.99.2 , ENZYME:EC:4.1.99.2 , IUBMB-ExplorEnz:EC:4.1.99.2 , UniProt:RELATED-TO:O30971 , UniProt:RELATED-TO:P31012 , UniProt:RELATED-TO:Q08897


References

Kumagai70: Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. II. Cofactor requrements." J Biol Chem 245(7);1773-7. PMID: 4908869

Kumagai70a: Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. I. Purification, crystallization, and properties." J Biol Chem 245(7);1767-72. PMID: 4908868

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.