MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tyrosine phenol-lyase

Enzyme Commission Synonyms: β-tyrosinase, L-tyrosine phenol-lyase (deaminating)

Taxonomic Range: Bacteria

L-tyrosine = phenol + 2-aminoprop-2-enoate + H+,
2-aminoprop-2-enoate → 2-iminopropanoate,
2-iminopropanoate + H+ + H2O → pyruvate + ammonium

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.35287666Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme also slowly catalyses pyruvate formation from D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.

Citations: [Kumagai70, Kumagai70a]

Unification Links: KEGG:R00728, Rhea:21707

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O30971, UniProt:RELATED-TO:P31012, UniProt:RELATED-TO:Q08897


Kumagai70: Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. II. Cofactor requrements." J Biol Chem 245(7);1773-7. PMID: 4908869

Kumagai70a: Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. I. Purification, crystallization, and properties." J Biol Chem 245(7);1767-72. PMID: 4908868

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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