Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.99.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.99.1

Enzymes and Genes:
tryptophanase / L-cysteine desulfhydrase : tnaA ( Escherichia coli K-12 substr. MG1655 )
tryptophanase : tna1 ( Symbiobacterium thermophilum )
tryptophanase ( Paenibacillus alvei )
tryptophanase : tnaA ( Enterobacter aerogenes )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tryptophanase

Enzyme Commission Synonyms: L-tryptophanase, L-tryptophan indole-lyase (deaminating)

Sub-reactions:
L-tryptophan ↔ indole + 2-aminoprop-2-enoate + H+ ,
2-aminoprop-2-enoate → 2-iminopropanoate ,
2-iminopropanoate + H+ + H2O → pyruvate + ammonium

Standard Gibbs Free Energy (ΔrG in kcal/mol): 5.1028786 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein, requiring K+. Also catalyses 2,3-elimination and β-replacement reactions of some indole-substituted tryptophan analogues of L-cysteine, L-serine and other 3-substituted amino acids.

Citations: [Newton65, Burns62]

Unification Links: KEGG:R00673 , Rhea:19553

Relationship Links: BRENDA:EC:4.1.99.1 , ENZYME:EC:4.1.99.1 , IUBMB-ExplorEnz:EC:4.1.99.1 , UniProt:RELATED-TO:P0A853 , UniProt:RELATED-TO:P28796 , UniProt:RELATED-TO:P31014 , UniProt:RELATED-TO:P31015


References

Burns62: Burns RO, Demoss RD (1962). "Properties of tryptophanase from Escherichia coli." Biochim Biophys Acta 65;233-44. PMID: 14017164

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Newton65: Newton WA, Morino Y, Snell EE (1965). "Properties of crystalline tryptophanase." J Biol Chem 240;1211-8. PMID: 14284727


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.