|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Pseudomonas fluorescens:||tryptophan side chain oxidase / tryptophan 2'-dioxygenase|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: tryptophan 2′-dioxygenase
Enzyme Commission Synonyms: indole-3-alkane α-hydroxylase, tryptophan side-chain α,β-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan α-hydroxylase, tryptophan side chain oxidase type I, TSO I , TSO II, tryptophan side chain oxidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -109.23899 [Latendresse13]
Enzyme Commission Summary:
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.
Roberts77: Roberts J, Rosenfeld HJ (1977). "Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme." J Biol Chem 252(8);2640-7. PMID: 15994
Takai77: Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T (1977). "Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives." J Biol Chem 252(8);2648-56. PMID: 15995
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