Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.13.99.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.13.99.3

Enzymes and Genes:
tryptophan side chain oxidase / tryptophan 2'-dioxygenase Inferred from experiment ( Pseudomonas fluorescens )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: tryptophan 2′-dioxygenase

Enzyme Commission Synonyms: indole-3-alkane α-hydroxylase, tryptophan side-chain α,β-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan α-hydroxylase, tryptophan side chain oxidase type I, TSO I , TSO II, tryptophan side chain oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -109.23899 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A hemoprotein. Acts on a number of indole-3-alkane derivatives, oxidizing the 3-side-chain in the 2'-position. Best substrates were L-tryptophan and 5-hydroxy-L-tryptophan.

Citations: [Roberts77, Takai77]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00681 , Rhea:22620

Relationship Links: BRENDA:EC:1.13.99.3 , ENZYME:EC:1.13.99.3 , IUBMB-ExplorEnz:EC:1.13.99.3

Credits:
Revised 13-Sep-2012 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Roberts77: Roberts J, Rosenfeld HJ (1977). "Isolation, crystallization, and properties of indolyl-3-alkane alpha-hydroxylase. A novel tryptophan-metabolizing enzyme." J Biol Chem 252(8);2640-7. PMID: 15994

Takai77: Takai K, Ushiro H, Noda Y, Narumiya S, Tokuyama T (1977). "Crystalline hemoprotein from Pseudomonas that catalyzes oxidation of side chain of tryptophan and other indole derivatives." J Biol Chem 252(8);2648-56. PMID: 15995


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc13.