|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Homo sapiens:||trimethyllysine dioxygenase: TMLHE|
|Rattus norvegicus:||ε-N-trimethyllysine hydroxylase: Tmlhe|
In Pathway: L-carnitine biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: trimethyllysine dioxygenase
Enzyme Commission Synonyms: trimethyllysine α-ketoglutarate dioxygenase, TML-α-ketoglutarate dioxygenase, TML hydroxylase, 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -109.620026 [Latendresse13]
Enzyme Commission Summary:
Requires Fe2+ and ascorbate.
Hulse78: Hulse JD, Ellis SR, Henderson LM (1978). "Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase." J Biol Chem 253(5);1654-9. PMID: 627563
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