Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.14.11.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.11.8

Enzymes and Genes:
trimethyllysine dioxygenase Inferred from experiment : TMLHE ( Homo sapiens )
ε-N-trimethyllysine hydroxylase Inferred from experiment : Tmlhe ( Rattus norvegicus )

In Pathway: L-carnitine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trimethyllysine dioxygenase

Enzyme Commission Synonyms: trimethyllysine α-ketoglutarate dioxygenase, TML-α-ketoglutarate dioxygenase, TML hydroxylase, 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -109.620026 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+ and ascorbate.

Citations: [Hulse78]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03451 , Rhea:14181

Relationship Links: BRENDA:EC:1.14.11.8 , ENZYME:EC:1.14.11.8 , IUBMB-ExplorEnz:EC:1.14.11.8


References

Hulse78: Hulse JD, Ellis SR, Henderson LM (1978). "Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase." J Biol Chem 253(5);1654-9. PMID: 627563

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC13B.