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MetaCyc Reaction: 1.14.11.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.11.8

Enzymes and Genes:

Homo sapiens : trimethyllysine dioxygenase Inferred from experiment : TMLHE
Rattus norvegicus : ε-N-trimethyllysine hydroxylase Inferred from experiment : Tmlhe

In Pathway: L-carnitine biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: trimethyllysine dioxygenase

Enzyme Commission Synonyms: trimethyllysine α-ketoglutarate dioxygenase, TML-α-ketoglutarate dioxygenase, TML hydroxylase, 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -109.620026 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+ and ascorbate.

Citations: [Hulse78]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03451 , Rhea:14181

Relationship Links: BRENDA:EC:1.14.11.8 , ENZYME:EC:1.14.11.8 , IUBMB-ExplorEnz:EC:1.14.11.8


References

Hulse78: Hulse JD, Ellis SR, Henderson LM (1978). "Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase." J Biol Chem 253(5);1654-9. PMID: 627563

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Sep 4, 2015, biocyc12.