MetaCyc Reaction: cystine/glutamate antiport

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsTransport ReactionsTransport Energised by the Membrane Electrochemical Gradient
Reactions Classified By SubstrateSmall-Molecule Reactions

Transporters and Genes:

Homo sapiens: cystine/glutamate antiporter system xc-Inferred from experiment: SLC3A2, SLC7A11

Transport reaction diagram

Reaction Locations: extracellular space/cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.0Inferred by computational analysis [Latendresse13]

Citations: [Lo08]

Gene-Reaction Schematic

Gene-Reaction Schematic

Created 23-Oct-2009 by Fulcher CA, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lo08: Lo M, Wang YZ, Gout PW (2008). "The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases." J Cell Physiol 215(3);593-602. PMID: 18181196

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC14A.