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MetaCyc Reaction: cystine/glutamate antiport

Superclasses: Reactions Classified By Conversion Type Simple Reactions Transport Reactions Transport Energised by the Membrane Electrochemical Gradient
Reactions Classified By Substrate Small-Molecule Reactions

Transporters and Genes:

Homo sapiens : cystine/glutamate antiporter system xc- Inferred from experiment : SLC3A2 , SLC7A11

Transport reaction diagram

Reaction Locations: extracellular space/cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.0 Inferred by computational analysis [Latendresse13]

Citations: [Lo08]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [an aromatic amino acid[cytosol] → an aromatic amino acid[periplasmic space]] (no EC#):
i1: L-phenylalanine[out] → L-phenylalanine[in] (no EC#)

i2: L-tryptophan[out] → L-tryptophan[in] (no EC#)

i3: L-tyrosine[out] → L-tyrosine[in] (no EC#)

Credits:
Created 23-Oct-2009 by Fulcher CA , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lo08: Lo M, Wang YZ, Gout PW (2008). "The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases." J Cell Physiol 215(3);593-602. PMID: 18181196


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Sep 1, 2015, biocyc11.