Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: cystine/glutamate antiport

Superclasses: Reactions Classified By Conversion Type Simple Reactions Transport Reactions Transport Energised by the Membrane Electrochemical Gradient
Reactions Classified By Substrate Small-Molecule Reactions

Transporters and Genes:
cystine/glutamate antiporter system xc- Inferred from experiment : SLC3A2 , SLC7A11 ( Homo sapiens )

Reaction Locations: extracellular space/cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.0 Inferred by computational analysis [Latendresse13]

Citations: [Lo08]

Gene-Reaction Schematic: ?

Instance reactions of [an L-amino acid[cytosol] → an L-amino acid[periplasmic space]] (no EC#):
i2: L-arginine[out] → L-arginine[in] (no EC#)

i7: L-leucine[out] → L-leucine[in] (no EC#)

i8: L-phenylalanine[out] → L-phenylalanine[in] (no EC#)

Instance reactions of [an aromatic amino acid[cytosol] → an aromatic amino acid[periplasmic space]] (no EC#):
i9: L-tryptophan[out] → L-tryptophan[in] (no EC#)

i10: L-tyrosine[out] → L-tyrosine[in] (no EC#)

Credits:
Created 23-Oct-2009 by Fulcher CA , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lo08: Lo M, Wang YZ, Gout PW (2008). "The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases." J Cell Physiol 215(3);593-602. PMID: 18181196


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC13B.