Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.14.99.10

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.99.10

Enzymes and Genes:
steroid 21-monooxygenase : CYP21A2 ( Homo sapiens )

Supersedes EC numbers: 1.99.1.11, 1.14.1.8

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Marked as unbalanced.

Enzyme Commission Primary Name: steroid 21-monooxygenase

Enzyme Commission Synonyms: steroid 21-hydroxylase, 21-hydroxylase, P450c21, CYP21A2 (gene name)

Enzyme Commission Summary:
Requires NADPH and EC 1.6.2.4, NADPH--hemoprotein reductase. A heme-thiolate protein (P-450) enzyme responsible for the conversion of progesterone and 17-α-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-desoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol.

Citations: [RYAN57, Dorfman52, Plager53, Kominami80, Martineau03, Arase06]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02130

Relationship Links: BRENDA:EC:1.14.99.10 , ENZYME:EC:1.14.99.10 , IUBMB-ExplorEnz:EC:1.14.99.10 , UniProt:RELATED-TO:P00191 , UniProt:RELATED-TO:P03940 , UniProt:RELATED-TO:P08686 , UniProt:RELATED-TO:P15540 , UniProt:RELATED-TO:Q7M366


References

Arase06: Arase M, Waterman MR, Kagawa N (2006). "Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli." Biochem Biophys Res Commun 344(1);400-5. PMID: 16597434

Dorfman52: Dorfman RI, Hayano M (1952). "The action of adrenal homogenates on progesterone, 17-hydroxyprogesterone and 21-desoxycortisone." Arch Biochem Biophys 36(1);237-9. PMID: 14934270

Kominami80: Kominami S, Ochi H, Kobayashi Y, Takemori S (1980). "Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation." J Biol Chem 255(8);3386-94. PMID: 6767716

Martineau03: Martineau I, Belanger A, Tchernof A, Tremblay Y (2003). "Molecular cloning and expression of guinea pig cytochrome P450c21 cDNA (steroid 21-hydroxylase) isolated from the adrenals." J Steroid Biochem Mol Biol 86(2);123-32. PMID: 14568563

Plager53: Plager JE, Samuels LT (1953). "Synthesis of C14-17-hydroxy-11-desoxycorticosterone and 17-hydroxycorticosterone by fractionated extracts of adrenal homogenates." Arch Biochem Biophys 42(2);477-8. PMID: 13031650

RYAN57: RYAN KJ, ENGEL LL (1957). "Hydroxylation of steroids at carbon 21." J Biol Chem 225(1);103-14. PMID: 13416221


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, BIOCYC14B.