|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 1.14.14.l
Enzymes and Genes:
|Homo sapiens:||steroid 21-monooxygenase: CYP21A2|
Supersedes EC number: 126.96.36.199
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: steroid 21-monooxygenase
Enzyme Commission Synonyms: steroid 21-hydroxylase, 21-hydroxylase, P450c21, CYP21A2 (gene name)
Taxonomic Range: Metazoa
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -30.84675 [Latendresse13]
Enzyme Commission Summary:
Requires NADPH and EC 188.8.131.52, NADPH--hemoprotein reductase. A heme-thiolate protein (P-450) enzyme responsible for the conversion of progesterone and 17-α-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-desoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol.
Unification Links: KEGG:R02130
Arase06: Arase M, Waterman MR, Kagawa N (2006). "Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli." Biochem Biophys Res Commun 344(1);400-5. PMID: 16597434
Kominami80: Kominami S, Ochi H, Kobayashi Y, Takemori S (1980). "Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation." J Biol Chem 255(8);3386-94. PMID: 6767716
Martineau03: Martineau I, Belanger A, Tchernof A, Tremblay Y (2003). "Molecular cloning and expression of guinea pig cytochrome P450c21 cDNA (steroid 21-hydroxylase) isolated from the adrenals." J Steroid Biochem Mol Biol 86(2);123-32. PMID: 14568563
Plager53: Plager JE, Samuels LT (1953). "Synthesis of C14-17-hydroxy-11-desoxycorticosterone and 17-hydroxycorticosterone by fractionated extracts of adrenal homogenates." Arch Biochem Biophys 42(2);477-8. PMID: 13031650
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