|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 184.108.40.206
Supersedes EC numbers: 220.127.116.11, 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Marked as unbalanced.
Enzyme Commission Primary Name: steroid 21-monooxygenase
Enzyme Commission Synonyms: steroid 21-hydroxylase, 21-hydroxylase, P450c21, CYP21A2 (gene name)
Taxonomic Range: Metazoa
Enzyme Commission Summary:
Requires NADPH and EC 22.214.171.124, NADPH--hemoprotein reductase. A heme-thiolate protein (P-450) enzyme responsible for the conversion of progesterone and 17-α-hydroxyprogesterone to their respective 21-hydroxylated derivatives, 11-deoxycorticosterone and 11-desoxycortisol. Involved in the biosynthesis of the hormones aldosterone and cortisol.
Unification Links: KEGG:R02130
Relationship Links: BRENDA:EC:126.96.36.199 , ENZYME:EC:188.8.131.52 , IUBMB-ExplorEnz:EC:184.108.40.206 , UniProt:RELATED-TO:P00191 , UniProt:RELATED-TO:P03940 , UniProt:RELATED-TO:P08686 , UniProt:RELATED-TO:P15540 , UniProt:RELATED-TO:Q7M366
Arase06: Arase M, Waterman MR, Kagawa N (2006). "Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli." Biochem Biophys Res Commun 344(1);400-5. PMID: 16597434
Kominami80: Kominami S, Ochi H, Kobayashi Y, Takemori S (1980). "Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation." J Biol Chem 255(8);3386-94. PMID: 6767716
Martineau03: Martineau I, Belanger A, Tchernof A, Tremblay Y (2003). "Molecular cloning and expression of guinea pig cytochrome P450c21 cDNA (steroid 21-hydroxylase) isolated from the adrenals." J Steroid Biochem Mol Biol 86(2);123-32. PMID: 14568563
Plager53: Plager JE, Samuels LT (1953). "Synthesis of C14-17-hydroxy-11-desoxycorticosterone and 17-hydroxycorticosterone by fractionated extracts of adrenal homogenates." Arch Biochem Biophys 42(2);477-8. PMID: 13031650
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