MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
phytosphingosine + a very long chain fatty acyl-CoA → a (4R)-4-hydroxysphinganine ceramide + coenzyme A + H+ (

sphinganine + a long-chain acyl-CoA → a dihydroceramide + coenzyme A + H+ (2.3.1.-)

sphinganine + a long-chain acyl-CoA → a dihydroceramide + coenzyme A + H+ (no EC#)

Enzyme Commission Primary Name: sphingosine N-acyltransferase

Enzyme Commission Synonyms: ceramide synthetase, sphingosine acyltransferase

Taxonomic Range: Fungi , Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 333.65692 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on sphingosine or its 2-epimer.

Citations: [Sribney66]

Unification Links: KEGG:R01496 , Rhea:23768

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sribney66: Sribney M (1966). "Enzymatic synthesis of ceramide." Biochim Biophys Acta 125(3);542-7. PMID: 5973195

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, biocyc13.