MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reactions:
D-erythro-sphinganine + a long-chain acyl-CoA → a dihydroceramide + coenzyme A + H+ (2.3.1.-)

D-erythro-sphinganine + a long-chain acyl-CoA → a dihydroceramide + coenzyme A + H+ (no EC#)

phytosphingosine + a very long chain fatty acyl-CoA → a phytoceramide + coenzyme A + H+ (

Enzyme Commission Primary Name: sphingosine N-acyltransferase

Enzyme Commission Synonyms: ceramide synthetase, sphingosine acyltransferase

Taxonomic Range: Fungi, Metazoa

Standard Gibbs Free Energy (ΔrG in kcal/mol): 333.65692Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on sphingosine or its 2-epimer.

Citations: [Sribney66]

Unification Links: KEGG:R01496, Rhea:23768

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sribney66: Sribney M (1966). "Enzymatic synthesis of ceramide." Biochim Biophys Acta 125(3);542-7. PMID: 5973195

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Tue Dec 1, 2015, BIOCYC13A.