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MetaCyc Reaction: 3.1.2.12

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.2.12

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : S-formylglutathione hydrolase Inferred from experiment : yeiG
S-formylglutathione hydrolase Inferred from experiment : frmB
Homo sapiens : S-formylglutathione hydrolase Inferred from experiment
Paracoccus denitrificans : S-formylglutathione hydrolase Inferred from experiment : fghA

In Pathway: formaldehyde oxidation II (glutathione-dependent)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: S-formylglutathione hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.1671143 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also hydrolyses S-acetylglutathione, but more slowly.

Citations: [Uotila74, Uotila73, Harms96]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00527 , Rhea:14961

Relationship Links: BRENDA:EC:3.1.2.12 , ENZYME:EC:3.1.2.12 , IUBMB-ExplorEnz:EC:3.1.2.12


References

Harms96: Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?." J Bacteriol 178(21);6296-9. PMID: 8892832

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uotila73: Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases." Biochemistry 12(20);3938-43. PMID: 4200890

Uotila74: Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver." J Biol Chem 249(23);7664-72. PMID: 4436331


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Jul 28, 2015, biocyc14.