Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.2.12

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.2.12

Enzymes and Genes:
S-formylglutathione hydrolase Inferred from experiment : frmB ( Escherichia coli K-12 substr. MG1655 )
S-formylglutathione hydrolase Inferred from experiment : yeiG ( Escherichia coli K-12 substr. MG1655 )
S-formylglutathione hydrolase Inferred from experiment ( Homo sapiens )
S-formylglutathione hydrolase Inferred from experiment : fghA ( Paracoccus denitrificans )

In Pathway: formaldehyde oxidation II (glutathione-dependent)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: S-formylglutathione hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.1671143 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also hydrolyses S-acetylglutathione, but more slowly.

Citations: [Uotila74, Uotila73, Harms96b]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00527 , Rhea:14961

Relationship Links: BRENDA:EC:3.1.2.12 , ENZYME:EC:3.1.2.12 , IUBMB-ExplorEnz:EC:3.1.2.12


References

Harms96b: Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?." J Bacteriol 178(21);6296-9. PMID: 8892832

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uotila73: Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases." Biochemistry 12(20);3938-43. PMID: 4200890

Uotila74: Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver." J Biol Chem 249(23);7664-72. PMID: 4436331


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC13A.