MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: S-formylglutathione hydrolaseInferred from experiment: yeiG
S-formylglutathione hydrolaseInferred from experiment: frmB
Homo sapiens: S-formylglutathione hydrolaseInferred from experiment
Paracoccus denitrificans: S-formylglutathione hydrolaseInferred from experiment: fghA

In Pathway: formaldehyde oxidation II (glutathione-dependent)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: S-formylglutathione hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -5.1671143Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also hydrolyses S-acetylglutathione, but more slowly.

Citations: [Uotila74, Uotila73 , Harms96 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00527, Rhea:14961

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Harms96: Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?." J Bacteriol 178(21);6296-9. PMID: 8892832

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uotila73: Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases." Biochemistry 12(20);3938-43. PMID: 4200890

Uotila74: Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver." J Biol Chem 249(23);7664-72. PMID: 4436331

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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