|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Homo sapiens :||catechol O-methyltransferase, membrane-bound form
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
a catechol + S-adenosyl-L-methionine → a guaiacol + S-adenosyl-L-homocysteine + H+ (188.8.131.52)
Enzyme Commission Primary Name: catechol O-methyltransferase
Enzyme Commission Synonyms: COMT I , COMT II, S-COMT (soluble form of catechol-O-methyltransferase), MB-COMT (membrane-bound form of catechol-O-methyltransferase), catechol methyltransferase, catecholamine O-methyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -4.3600006 [Latendresse13]
Enzyme Commission Summary:
The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.
Unification Links: KEGG:R04301
Huh79: Huh MM, Friedhoff AJ (1979). "Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization." J Biol Chem 254(2);299-308. PMID: 762061
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