MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : ribonucleoside-triphosphate reductase Inferred from experiment : nrdD

In Pathway: guanosine deoxyribonucleotides de novo biosynthesis II

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribonucleoside-triphosphate reductase

Enzyme Commission Synonyms: ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -28.600891 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires a cobamide coenzyme and ATP.

Citations: [Blakley65, Goulian66]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Blakley65: Blakley RL (1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii." J Biol Chem 240;2173-80. PMID: 14299643

Goulian66: Goulian M, Beck WS (1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii." J Biol Chem 241(18);4233-42. PMID: 5924645

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc14.