Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.3.1.21

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.21

Enzymes and Genes:
carnitine O-palmitoyltransferase 2 Inferred from experiment : CPT2 ( Homo sapiens )
carnitine O-palmitoyltransferase 1, brain isoform : CPT1C ( Homo sapiens )
carnitine O-palmitoyltransferase 1, muscle isoform Inferred from experiment : CPT1B ( Homo sapiens )
carnitine O-palmitoyltransferase 1, liver isoform : CPT1A ( Homo sapiens )
carnitine palmitoyltransferase 2 Inferred from experiment : Cpt2 ( Rattus norvegicus )
carnitine palmitoyltransferase 1a Inferred from experiment : Cpt1a ( Rattus norvegicus )

In Pathway: mitochondrial L-carnitine shuttle

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Reaction Locations: mitochondrial lumen, cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Instance reaction:
L-carnitine + palmitoyl-CoA = L-palmitoylcarnitine + coenzyme A (2.3.1.21)

Enzyme Commission Primary Name: carnitine O-palmitoyltransferase

Enzyme Commission Synonyms: CPT, CPTo, outer malonyl-CoA inhibitable carnitine palmitoyltransferase, CPTi, CPT I (outer membrane carnitine palmitoyl transferase), carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, CPT-A, CPT-B, acylcarnitine transferase, carnitine palmitoyltransferase, carnitine palmitoyltransferase-A, L-carnitine palmitoyltransferase, palmitoylcarnitine transferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 170.99902 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.

Citations: [Healy88, Miyazawa83, Derrick86]

Gene-Reaction Schematic: ?

Instance reaction of [a long-chain acyl-CoA + L-carnitine ↔ an O-acyl-L-carnitine + coenzyme A] (2.3.1.21):
i1: L-carnitine + palmitoyl-CoA = L-palmitoylcarnitine + coenzyme A (2.3.1.21)

Relationship Links: BRENDA:EC:2.3.1.21 , ENZYME:EC:2.3.1.21 , IUBMB-ExplorEnz:EC:2.3.1.21


References

Derrick86: Derrick JP, Tubbs PK, Ramsay RR (1986). "Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria." Biochem. Soc. Trans. 14 698.

Healy88: Healy MJ, Kerner J, Bieber LL (1988). "Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?." Biochem J 249(1);231-7. PMID: 3342008

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa83: Miyazawa S, Ozasa H, Osumi T, Hashimoto T (1983). "Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver." J Biochem 94(2);529-42. PMID: 6630173


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14B.