Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 2.3.1.21

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.3.1.21

Enzymes and Genes:

Homo sapiens: carnitine O-palmitoyltransferase 1, muscle isoformInferred from experiment: CPT1B
carnitine O-palmitoyltransferase 2Inferred from experiment: CPT2
carnitine O-palmitoyltransferase 1, liver isoform: CPT1A
carnitine O-palmitoyltransferase 1, brain isoform: CPT1C
Rattus norvegicus: carnitine palmitoyltransferase 1aInferred from experiment: Cpt1a
carnitine palmitoyltransferase 2Inferred from experiment: Cpt2

In Pathway: mitochondrial L-carnitine shuttle

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Reaction Locations: mitochondrial lumen, cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Instance reaction:
palmitoyl-CoA + L-carnitine → L-palmitoylcarnitine + coenzyme A (2.3.1.21)

Enzyme Commission Primary Name: carnitine O-palmitoyltransferase

Enzyme Commission Synonyms: CPT, CPTo, outer malonyl-CoA inhibitable carnitine palmitoyltransferase, CPTi, CPT I (outer membrane carnitine palmitoyl transferase), carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, CPT-A, CPT-B, acylcarnitine transferase, carnitine palmitoyltransferase, carnitine palmitoyltransferase-A, L-carnitine palmitoyltransferase, palmitoylcarnitine transferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 170.99902Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.

Citations: [Healy88, Miyazawa83, Derrick86]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a long-chain acyl-CoA + L-carnitine ↔ an O-acyl-L-carnitine + coenzyme A] (2.3.1.21):
i1: palmitoyl-CoA + L-carnitine → L-palmitoylcarnitine + coenzyme A (2.3.1.21)

Relationship Links: BRENDA:EC:2.3.1.21, ENZYME:EC:2.3.1.21, IUBMB-ExplorEnz:EC:2.3.1.21


References

Derrick86: Derrick JP, Tubbs PK, Ramsay RR (1986). "Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria." Biochem. Soc. Trans. 14 698.

Healy88: Healy MJ, Kerner J, Bieber LL (1988). "Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?." Biochem J 249(1);231-7. PMID: 3342008

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Miyazawa83: Miyazawa S, Ozasa H, Osumi T, Hashimoto T (1983). "Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver." J Biochem 94(2);529-42. PMID: 6630173


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 6, 2016, biocyc13.