|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
Enzymes and Genes:
|Homo sapiens:||carnitine O-palmitoyltransferase 1, muscle isoform: CPT1B|
carnitine O-palmitoyltransferase 2: CPT2
carnitine O-palmitoyltransferase 1, liver isoform: CPT1A
carnitine O-palmitoyltransferase 1, brain isoform: CPT1C
|Rattus norvegicus:||carnitine palmitoyltransferase 1a: Cpt1a|
carnitine palmitoyltransferase 2: Cpt2
In Pathway: mitochondrial L-carnitine shuttle
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
Reaction Locations: mitochondrial lumen, cytosol
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
palmitoyl-CoA + L-carnitine → L-palmitoylcarnitine + coenzyme A (188.8.131.52)
Enzyme Commission Primary Name: carnitine O-palmitoyltransferase
Enzyme Commission Synonyms: CPT, CPTo, outer malonyl-CoA inhibitable carnitine palmitoyltransferase, CPTi, CPT I (outer membrane carnitine palmitoyl transferase), carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, CPT-A, CPT-B, acylcarnitine transferase, carnitine palmitoyltransferase, carnitine palmitoyltransferase-A, L-carnitine palmitoyltransferase, palmitoylcarnitine transferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 170.99902 [Latendresse13]
Enzyme Commission Summary:
Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 184.108.40.206 carnitine O-acetyltransferase and EC 220.127.116.11 carnitine O-octanoyltransferase.
Instance reaction of [a long-chain acyl-CoA + L-carnitine ↔ an O-acyl-L-carnitine + coenzyme A] (18.104.22.168):
i1: palmitoyl-CoA + L-carnitine → L-palmitoylcarnitine + coenzyme A (22.214.171.124)
Healy88: Healy MJ, Kerner J, Bieber LL (1988). "Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?." Biochem J 249(1);231-7. PMID: 3342008
Miyazawa83: Miyazawa S, Ozasa H, Osumi T, Hashimoto T (1983). "Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver." J Biochem 94(2);529-42. PMID: 6630173
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