Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.1.2.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 3.1.2.14

Enzymes and Genes:
fatty acid synthase Inferred from experiment : FASN ( Homo sapiens )

In Pathway: palmitate biosynthesis II (bacteria and plants) , palmitate biosynthesis I (animals and fungi)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: oleoyl-[acyl-carrier-protein] hydrolase

Enzyme Commission Synonyms: acyl-[acyl-carrier-protein] hydrolase, acyl-ACP-hydrolase, acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, oleoyl-acyl carrier protein thioesterase, oleoyl-[acyl-carrier-protein] hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 302.0365 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on acyl-carrier-protein thioesters of fatty acids from C12 to C18, but the derivative of oleic acid is hydrolysed much more rapidly than any other compound tested.

Citations: [Thomas05, Ohlrogge78, Shine76]

Gene-Reaction Schematic: ?

Unification Links: Rhea:30130

Relationship Links: BRENDA:EC:3.1.2.14 , ENZYME:EC:3.1.2.14 , IUBMB-ExplorEnz:EC:3.1.2.14


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ohlrogge78: Ohlrogge JB, Shine WE, Stumpf PK (1978). "Fat metabolism in higher plants. Characterization of plant acyl-ACP and acyl-CoA hydrolases." Arch Biochem Biophys 189(2);382-91. PMID: 30409

Shine76: Shine WE, Mancha M, Stumpf PK (1976). "Fat metabolism in higher plants. The function of acyl thioesterases in the metabolism of acyl-coenzymes A and acyl-acyl carrier proteins." Arch Biochem Biophys 172(1);110-6. PMID: 3134

Thomas05: Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization." J Biol Chem 280(41);34675-83. PMID: 16107329


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc11.