MetaCyc Reaction: 4.2.1.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.-

Enzymes and Genes:

Candida albicans SC5314 : enoyl-CoA hydratase : FOX2
Cucumis sativus : very-long-chain 3-hydroxyacyl-CoA dehydratase
Homo sapiens : peroxisomal multifunctional enzyme type 2 : HSD17B4
Pseudomonas oleovorans : (R)-specific enoyl-CoA hydratase : phaJ1
Rattus norvegicus : 3-hydroxyacyl-CoA dehydrase Inferred from experiment
Saccharomyces cerevisiae : peroxisomal multifunctional enzyme type 2 : FOX2

In Pathway: stearate biosynthesis I (animals and fungi)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4.2.1 -- Hydro-lyases

Standard Gibbs Free Energy (ΔrG in kcal/mol): 2.1629639 Inferred by computational analysis [Latendresse13]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a (3R)-3-hydroxyacyl-CoA ↔ a trans-2-enoyl-CoA + H2O] (
i1: (3R)-3-hydroxy-stearoyl-CoA → trans-octadec-2-enoyl-CoA + H2O (4.2.1.-)

Unification Links: KEGG:R07760


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Oct 9, 2015, BIOCYC11A.