|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Arabidopsis thaliana col :||3-oxoacyl-[acyl-carrier-protein] reductase, chloroplastic
|Escherichia coli K-12 substr. MG1655 :||3-oxoacyl-[acyl-carrier-protein] reductase
|Homo sapiens :||fatty acid synthase
|Mycobacterium tuberculosis H37Rv :||fatty acid synthase
|Pseudomonas aeruginosa :||NADPH-dependent β-ketoacyl reductase
|Saccharomyces cerevisiae :||fatty acid synthase, α subunit
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ ← a 3-oxoacyl-[acp] + NADPH + H+ (18.104.22.168)
Enzyme Commission Primary Name: fatty-acyl-CoA synthase
Enzyme Commission Synonyms: yeast fatty acid synthase, FAS1 (gene name), FAS2 (gene name)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 20.375793 [Latendresse13]
Enzyme Commission Summary:
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 22.214.171.124, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 126.96.36.199, β-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 188.8.131.52, [acyl-carrier-protein] S-acetyltransferase, EC 184.108.40.206, [acyl-carrier-protein] S-malonyltransferase, EC 220.127.116.11, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 18.104.22.168, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 22.214.171.1249, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme differs from the animal enzyme (EC 126.96.36.199) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Instance reaction of [a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ ← a 3-oxoacyl-[acp] + NADPH + H+] (188.8.131.52):
i1: a (3R)-3-hydroxyoctanoyl-[acp] + NADP+ ← a 3-oxo-octanoyl-[acp] + NADPH + H+ (184.108.40.206)
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