Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.2.1.84

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.84

Enzymes and Genes:
pheromone gland-specific fatty-acyl reductase Inferred from experiment : FAR ( Bombyx mori )
alcohol-forming fatty acyl-CoA reductase Inferred from experiment : FAR ( Simmondsia chinensis )

In Pathway: wax esters biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alcohol-forming fatty acyl-CoA reductase

Enzyme Commission Synonyms: FAR (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 294.2744 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme has been characterized from the plant Simmondsia chinensis (jojoba). The alcohol is formed by a four-electron reduction of fatty acyl-CoA. Although the reaction proceeds through an aldehyde intermediate, a free aldehyde is not released. The recombinant enzyme was shown to accept saturated and mono-unsaturated fatty acyl-CoAs of 16 to 22 carbons.

Citations: [Metz00]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.2.1.84 , ENZYME:EC:1.2.1.84 , IUBMB-ExplorEnz:EC:1.2.1.84


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Metz00: Metz JG, Pollard MR, Anderson L, Hayes TR, Lassner MW (2000). "Purification of a jojoba embryo fatty acyl-coenzyme A reductase and expression of its cDNA in high erucic acid rapeseed." Plant Physiol 2000;122(3);635-44. PMID: 10712526


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, BIOCYC14B.