MetaCyc Reaction: 1.3.8.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.8.-

Enzymes and Genes:

Methylomonas sp. 16a : diapophytoene desaturase Inferred from experiment : crtN
Staphylococcus aureus : dehydrosqualene desaturase Inferred from experiment : crtN

Sub-reaction of: 15-cis-4,4'-diapophytoene + 4 FAD + 4 H+ = all-trans-4,4'-diapolycopene + 4 FADH2 ,
1.3.8.o: 15-cis-4,4'-diapophytoene + 3 FAD + 3 H+ = all-trans-4,4'-diaponeurosporene + 3 FADH2

In Pathway: staphyloxanthin biosynthesis , 4,4'-diapolycopenedioate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1.3.8 -- With a flavin as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): -19.315643 Inferred by computational analysis [Latendresse13]

This is one of several successive reactions catalyzed by 4,4'-diapophytoene desaturase.

Citations: [Raisig01, Wieland94]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:31402

Revised 15-Jun-2011 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Raisig01: Raisig A, Sandmann G (2001). "Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways." Biochim Biophys Acta 1533(2);164-70. PMID: 11566453

Wieland94: Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Gotz F (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus." J Bacteriol 176(24);7719-26. PMID: 8002598

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.