Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 2.6.1.86

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.6.1.86

Enzymes and Genes:
2-amino-4-deoxychorismate synthase Inferred from experiment : phzE ( Pseudomonas fluorescens 2-79 )

In Pathway: phenazine-1-carboxylate biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 2-amino-4-deoxychorismate synthase

Enzyme Commission Synonyms: ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD

Standard Gibbs Free Energy (ΔrG in kcal/mol): -2.0558853 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. The sequential action of this enzyme and EC 1.3.99.24, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027, which is essential for both binding and intercalating the minor groove of DNA [Van08, Yu95a]

Citations: [McDonald01, Laursen04]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R08956 , Rhea:25515

Relationship Links: BRENDA:EC:2.6.1.86 , ENZYME:EC:2.6.1.86 , IUBMB-ExplorEnz:EC:2.6.1.86


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Laursen04: Laursen JB, Nielsen J (2004). "Phenazine natural products: biosynthesis, synthetic analogues, and biological activity." Chem Rev 104(3);1663-86. PMID: 15008629

McDonald01: McDonald M, Mavrodi DV, Thomashow LS, Floss HG (2001). "Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid." J Am Chem Soc 123(38);9459-60. PMID: 11562236

Van08: Van Lanen SG, Lin S, Shen B (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism." Proc Natl Acad Sci U S A 105(2);494-9. PMID: 18182490

Yu95a: Yu, L., Mah, S., Otani, T., Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding." J. Am. Chem. Soc. 117:8877-8878.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC14A.