|Superclasses:||Reactions-Classified-By-Conversion-Type → Simple-Reactions → Chemical-Reactions|
|Reactions-Classified-By-Substrate → Small-Molecule-Reactions|
EC Number: 18.104.22.168
In Pathway: phenazine-1-carboxylate biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 2-amino-4-deoxychorismate synthase
Enzyme Commission Synonyms: ADIC synthase, 2-amino-2-deoxyisochorismate synthase, SgcD
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -2.0558853 [Latendresse13]
Enzyme Commission Summary:
Requires Mg2+. The reaction occurs in the reverse direction to that shown above. In contrast to most anthranilate-synthase I (ASI) homologues, this enzyme is not inhibited by tryptophan. The sequential action of this enzyme and EC 22.214.171.124, 2-amino-4-deoxychorismate dehydrogenase, leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027, which is essential for both binding and intercalating the minor groove of DNA [Van08, Yu95a]
McDonald01: McDonald M, Mavrodi DV, Thomashow LS, Floss HG (2001). "Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid." J Am Chem Soc 123(38);9459-60. PMID: 11562236
Van08: Van Lanen SG, Lin S, Shen B (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism." Proc Natl Acad Sci U S A 105(2);494-9. PMID: 18182490
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