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MetaCyc Reaction: 1.1.99.32

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.1.99.32

Enzymes and Genes:

Gluconobacter oxydans UV10: L-sorbose dehydrogenase, FAD dependentInferred from experiment: BAA13144
Ketogulonicigenium vulgare DSM 4025: L-sorbose dehydrogenaseTraceable author statement to experimental supportInferred from experiment

In Pathway: L-ascorbate biosynthesis III, 2-keto-L-gulonate biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: L-sorbose 1-dehydrogenase

Enzyme Commission Synonyms: SDH

Enzyme Commission Summary:
The product, L-sorbosone, is an intermediate in bacterial 2-keto-L-gulonic-acid formation. The activity of this membrane-bound enzyme is stimulated by Fe(III) or Co2+ but is inhibited by Cu2+. The enzyme is highly specific for L-sorbose as other sugars, such as glucose, mannitol and sorbitol, are not substrates. Phenazine methosulfate and DCIP can act as artificial acceptors.

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:24878

Relationship Links: BRENDA:EC:1.1.99.32, ENZYME:EC:1.1.99.32, IUBMB-ExplorEnz:EC:1.1.99.32


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Feb 5, 2016, biocyc12.