|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Homo sapiens:||ketimine reductase mu-crystallin: CRYM|
|Pseudomonas putida:||Δ1-piperideine-2-carboxylate reductase: dpkA|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
L-pipecolate + NAD+ = 1-piperideine-2-carboxylate + NADH + 2 H+ (22.214.171.124)
Enzyme Commission Primary Name: pyrroline-2-carboxylate reductase
Enzyme Commission Synonyms: δ1-pyrroline-2-carboxylate reductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -24.103516 [Latendresse13]
Enzyme Commission Summary:
The enzymes, characterized from from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 126.96.36.199, Δ1-piperideine-2-carboxylate reductase, which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
Instance reaction of [L-pipecolate + NAD(P)+ ← 1-piperideine-2-carboxylate + NAD(P)H + 2 H+] (188.8.131.52):
i1: L-pipecolate + NAD+ = 1-piperideine-2-carboxylate + NADH + 2 H+ (184.108.40.206)
Watanabe14: Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y (2014). "Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria." FEBS Open Bio 4;240-50. PMID: 24649405
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