|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 126.96.36.199
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
L-pipecolate + NAD+ = 1-piperideine-2-carboxylate + NADH + 2 H+ (188.8.131.52)
Enzyme Commission Primary Name: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
Enzyme Commission Synonyms: δ1-pyrroline-2-carboxylate reductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -24.103516 [Latendresse13]
Enzyme Commission Summary:
The enzymes, characterized from from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 184.108.40.206, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.
Instance reaction of [L-pipecolate + NAD(P)+ ← 1-piperideine-2-carboxylate + NAD(P)H + 2 H+] (220.127.116.11):
i1: L-pipecolate + NAD+ = 1-piperideine-2-carboxylate + NADH + 2 H+ (18.104.22.168)
Watanabe14: Watanabe S, Tanimoto Y, Yamauchi S, Tozawa Y, Sawayama S, Watanabe Y (2014). "Identification and characterization of trans-3-hydroxy-l-proline dehydratase and Δ(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria." FEBS Open Bio 4;240-50. PMID: 24649405
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