Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.5.1.21

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.1.21

Enzymes and Genes:
ketimine reductase mu-crystallin Inferred from experiment : CRYM ( Homo sapiens )
Δ1-piperideine-2-carboxylate reductase Inferred from experiment : dpkA ( Pseudomonas putida )

In Pathway: lysine degradation V , lysine degradation II (pipecolate pathway)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
L-pipecolate + NAD+ = Δ1-piperideine-2-carboxylate + NADH + 2 H+ (1.5.1.21)

Enzyme Commission Primary Name: Δ1-piperideine-2-carboxylate reductase

Enzyme Commission Synonyms: 1,2-didehydropipecolate reductase, P2C reductase, 1,2-didehydropipecolic reductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -24.103516 Inferred by computational analysis [Latendresse13]

Citations: [Payton82]

Gene-Reaction Schematic: ?

Instance reaction of [L-pipecolate + NAD(P)+ ← Δ1-piperideine-2-carboxylate + NAD(P)H + 2 H+] (1.5.1.21):
i1: L-pipecolate + NAD+ = Δ1-piperideine-2-carboxylate + NADH + 2 H+ (1.5.1.21)

Unification Links: KEGG:R02203 , Rhea:12524

Relationship Links: BRENDA:EC:1.5.1.21 , ENZYME:EC:1.5.1.21 , IUBMB-ExplorEnz:EC:1.5.1.21


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Payton82: Payton CW, Chang YF (1982). "delta1-piperideine-2-carboxylate reductase of Pseudomonas putida." J Bacteriol 149(3);864-71. PMID: 6801013


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc13.