Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 1.14.11.9

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.14.11.9

Enzymes and Genes:

Arabidopsis thaliana col: flavanone 3β-hydroxylaseInferred from experiment: TT6
Equisetum arvense: flavanone 3β-hydroxylaseInferred from experiment
Matthiola incana: flavanone 3β-hydroxylaseInferred from experiment
Petunia x hybrida: flavanone 3β-hydroxylaseInferred from experiment: AN3

In Pathway: leucopelargonidin and leucocyanidin biosynthesis, flavonoid biosynthesis (in equisetum)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Direct generic reaction:
a flavanone + 2-oxoglutarate + oxygen → a dihydroflavonol + succinate + CO2 (1.14.11.9)

Enzyme Commission Primary Name: flavanone 3-dioxygenase

Enzyme Commission Synonyms: naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3β-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -95.88101Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+ and ascorbate.

Citations: [Wellmann04, Forkmann80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03640

Relationship Links: BRENDA:EC:1.14.11.9, ENZYME:EC:1.14.11.9, IUBMB-ExplorEnz:EC:1.14.11.9


References

Forkmann80: Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana. Flavanone 3- and flavonoid 3'-hydroxylases." Z. Naturforsch. 35c, 691-695.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wellmann04: Wellmann F, Matern U, Lukacin R (2004). "Significance of C-terminal sequence elements for Petunia flavanone 3β-hydroxylase activity." FEBS Lett 561(1-3);149-54. PMID: 15013767


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue May 3, 2016, biocyc14.