MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: flavanone 3β-hydroxylaseInferred from experiment: TT6
Equisetum arvense: flavanone 3β-hydroxylaseInferred from experiment
Matthiola incana: flavanone 3β-hydroxylaseInferred from experiment
Petunia x hybrida: flavanone 3β-hydroxylaseInferred from experiment: AN3

In Pathway: leucopelargonidin and leucocyanidin biosynthesis, flavonoid biosynthesis (in equisetum)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Direct generic reaction:
a flavanone + 2-oxoglutarate + oxygen → a dihydroflavonol + succinate + CO2 (

Enzyme Commission Primary Name: flavanone 3-dioxygenase

Enzyme Commission Synonyms: naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3β-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -95.88101Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+ and ascorbate.

Citations: [Wellmann04, Forkmann80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03640

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Forkmann80: Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana. Flavanone 3- and flavonoid 3'-hydroxylases." Z. Naturforsch. 35c, 691-695.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wellmann04: Wellmann F, Matern U, Lukacin R (2004). "Significance of C-terminal sequence elements for Petunia flavanone 3β-hydroxylase activity." FEBS Lett 561(1-3);149-54. PMID: 15013767

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13A.