Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.14.11.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.11.9

Enzymes and Genes:
flavanone 3β-hydroxylase Inferred from experiment ( Equisetum arvense )
flavanone 3β-hydroxylase Inferred from experiment ( Matthiola incana )
flavanone 3β-hydroxylase Inferred from experiment : AN3 ( Petunia x hybrida )
flavanone 3β-hydroxylase Inferred from experiment : TT6 ( Arabidopsis thaliana col )

In Pathway: leucopelargonidin and leucocyanidin biosynthesis , flavonoid biosynthesis (in equisetum)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Direct generic reaction:
a flavanone + 2-oxoglutarate + oxygen → a dihydroflavonol + succinate + CO2 (1.14.11.9)

Enzyme Commission Primary Name: flavanone 3-dioxygenase

Enzyme Commission Synonyms: naringenin 3-hydroxylase, flavanone 3-hydroxylase, flavanone 3β-hydroxylase, flavanone synthase I, (2S)-flavanone 3-hydroxylase, naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -95.88101 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+ and ascorbate.

Citations: [Wellmann04, Forkmann80]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03640

Relationship Links: BRENDA:EC:1.14.11.9 , ENZYME:EC:1.14.11.9 , IUBMB-ExplorEnz:EC:1.14.11.9


References

Forkmann80: Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana. Flavanone 3- and flavonoid 3'-hydroxylases." Z. Naturforsch. 35c, 691-695.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wellmann04: Wellmann F, Matern U, Lukacin R (2004). "Significance of C-terminal sequence elements for Petunia flavanone 3β-hydroxylase activity." FEBS Lett 561(1-3);149-54. PMID: 15013767


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.