|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
In Pathway: glutathione amide metabolism
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glutathione amide-dependent peroxidase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -74.20401 [Latendresse13]
Enzyme Commission Summary:
This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress [Vergauwen01]. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 18.104.22.168 (glutathione amide reductase).
Unification Links: Rhea:27437
Vergauwen01: Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ (2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling." J Biol Chem 276(24);20890-7. PMID: 11399772
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