|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
glycerol-3-phosphate acyltransferase : plsB ( Escherichia coli K-12 substr. MG1655 )
glycerol-3-phosphate 1-O-acyltransferase : SCT1 ( Saccharomyces cerevisiae )
glycerol-3-phosphate acyltransferase : GPT2 ( Saccharomyces cerevisiae )
glycerol-3-phosphate O-acyltransferase : GPAT8 ( Arabidopsis thaliana col )
cytoplasmic glycerol-3-phosphate acyltransferase : GPAT2 ( Arabidopsis thaliana col )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glycerol-3-phosphate 1-O-acyltransferase
Enzyme Commission Synonyms: α-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, glycerol-3-phosphate O-acyltransferase (ambiguous)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 253.16797 [Latendresse13]
Enzyme Commission Summary:
Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme acts only on derivatives of fatty acids of chain length above C10.
Instance reaction of [a long-chain acyl-CoA + sn-glycerol 3-phosphate → a 1-acyl-sn-glycerol 3-phosphate + coenzyme A] (22.214.171.124):
i1: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = 1-C16:0-α,ω-dicarboxyl-2-lysophosphatidate + coenzyme A (126.96.36.199)
Bertrams81: Bertrams M, Heinz E (1981). "Positional Specificity and Fatty Acid Selectivity of Purified sn-Glycerol 3-Phosphate Acyltransferases from Chloroplasts." Plant Physiol 68(3);653-7. PMID: 16661974
Frentzen83: Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts." Eur J Biochem 129(3);629-36. PMID: 6825679
Green83: Green PR, Vanaman TC, Modrich P, Bell RM (1983). "Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase." J Biol Chem 258(18);10862-6. PMID: 6350296
Yamashita72: Yamashita S, Numa S (1972). "Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A." Eur J Biochem 31(3);565-73. PMID: 4650158
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