MetaCyc Reaction: 1.1.1.-

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.1.1.-

Enzymes and Genes:

Drosophila melanogaster : all-trans-3-hydroxyretinal dehydrogenase Inferred from experiment : Pdh

In Pathway: the visual cycle (insects)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
a (3R)-all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← a (3R)-all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+ (1.1.1.-)

Enzyme Commission Primary Name: 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.9857788 Inferred by computational analysis [Latendresse13]

Citations: [Wang10c]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [an all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← an all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+] (1.1.1.-):
i1: a (3R)-all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← a (3R)-all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+ (1.1.1.-)

Created 27-Apr-2012 by Caspi R , SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wang10c: Wang X, Wang T, Jiao Y, von Lintig J, Montell C (2010). "Requirement for an enzymatic visual cycle in Drosophila." Curr Biol 20(2);93-102. PMID: 20045325

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, biocyc13.