MetaCyc Reaction: 1.1.1.-

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number: 1.1.1.-

Enzymes and Genes:

Drosophila melanogaster: all-trans-3-hydroxyretinal dehydrogenaseInferred from experiment: Pdh

In Pathway: the visual cycle (insects)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
a (3R)-all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← a (3R)-all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+ (1.1.1.-)

Enzyme Commission Primary Name: 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.9857788Inferred by computational analysis [Latendresse13]

Citations: [Wang10]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← an all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+] (1.1.1.-):
i1: a (3R)-all-trans-3-hydroxyretinol-[retinoid-binding protein] + NADP+ ← a (3R)-all-trans-3-hydroxyretinal-[retinoid-binding protein] + NADPH + H+ (1.1.1.-)

Created 27-Apr-2012 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wang10: Wang X, Wang T, Jiao Y, von Lintig J, Montell C (2010). "Requirement for an enzymatic visual cycle in Drosophila." Curr Biol 20(2);93-102. PMID: 20045325

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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