|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.1680
Enzymes and Genes:
|Arabidopsis thaliana col:||very-long-chain 3-oxoacyl-CoA reductase: KCR1|
|Saccharomyces cerevisiae:||very-long-chain 3-oxoacyl-CoA reductase: IFA38|
In Pathway: very long chain fatty acid biosynthesis II
Supersedes EC number: 22.214.171.124
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: very-long-chain 3-oxoacyl-CoA reductase
Enzyme Commission Synonyms: very-long-chain 3-ketoacyl-CoA reductase, very-long-chain β-ketoacyl-CoA reductase, KCR (gene name), IFA38 (gene name)
Standard Gibbs Free Energy (ΔrG'°): -0.1663208 kcal/mol [Latendresse13]
Enzyme Commission Summary:
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain fatty acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 126.96.36.199, very-long-chain 3-oxoacyl-CoA synthase, EC 188.8.131.52, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 184.108.40.206, very-long-chain enoyl-CoA reductase.
Beaudoin02: Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA (2002). "A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase." J Biol Chem 277(13);11481-8. PMID: 11792704
Beaudoin09: Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L (2009). "Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase." Plant Physiol 150(3);1174-91. PMID: 19439572
Han02a: Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM (2002). "The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase." J Biol Chem 277(38);35440-9. PMID: 12087109
Wakil62: Wakil, S, Bressler, R (1962). "Studies on the mechanism of fatty acid synthesis. X. Reduced triphosphopyridine nucleotide-acetoacetyl coenzyme A reductase." J Biol Chem 237;687-93. PMID: 14004466
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