MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

Enzymes and Genes:
(2R,3R)-3-methylornithyl-N6-lysine synthase Inferred from experiment : pylC ( Methanosarcina acetivorans )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): 8.321777 Inferred by computational analysis [Latendresse13]

D-ornithine is an unnatural substrate.

Citations: [Gaston11, Cellitti11]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 15-Feb-2012 by Fulcher CA , SRI International


Cellitti11: Cellitti SE, Ou W, Chiu HP, Grunewald J, Jones DH, Hao X, Fan Q, Quinn LL, Ng K, Anfora AT, Lesley SA, Uno T, Brock A, Geierstanger BH (2011). "D-Ornithine coopts pyrrolysine biosynthesis to make and insert pyrroline-carboxy-lysine." Nat Chem Biol 7(8);528-30. PMID: 21525873

Gaston11: Gaston MA, Zhang L, Green-Church KB, Krzycki JA (2011). "The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine." Nature 471(7340);647-50. PMID: 21455182

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Mar 31, 2015, BIOCYC13B.