Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.3.1.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.9

Enzymes and Genes:
β-ketothiolase Inferred from experiment : bktB ( Cupriavidus necator )
β-ketoadipyl CoA thiolase : pcaF ( Pseudomonas putida )
3-ketoacyl-CoA thiolase : KAT2 ( Arabidopsis thaliana col )
peroxisomal 3-ketoacyl-CoA thiolase : ACAA1 ( Homo sapiens )
mitochondrial 3-ketoacyl-CoA thiolase : ACAA2 ( Homo sapiens )
Non-specific lipid-transfer protein : SCP2 ( Homo sapiens )
trifunctional enzyme beta subunit, mitochondrial precursor : HADHB ( Homo sapiens )
3-oxoacyl CoA thiolase : POT1 ( Saccharomyces cerevisiae )
fatty acid oxidation complex, β component : fadA ( Escherichia coli K-12 substr. MG1655 )
Fad I component of anaerobic fatty acid oxidation complex : fadI ( Escherichia coli K-12 substr. MG1655 )

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: acetyl-CoA C-acetyltransferase

Enzyme Commission Synonyms: acetoacetyl-CoA thiolase, β-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.0598145 Inferred by computational analysis [Latendresse13]

Citations: [Dekishima11, LYNEN, STERN60]

Gene-Reaction Schematic: ?

Instance reaction of [a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ↔ a 3-oxoacyl-CoA + coenzyme A] (2.3.1.16):
i1: acetyl-CoA + propanoyl-CoA = β-ketovaleryl-CoA + coenzyme A (2.3.1.9)

Relationship Links: BRENDA:EC:2.3.1.9 , ENZYME:EC:2.3.1.9 , IUBMB-ExplorEnz:EC:2.3.1.9

Credits:
Created 12-Aug-2011 by Caspi R , SRI International


References

Dekishima11: Dekishima Y, Lan EI, Shen CR, Cho KM, Liao JC (2011). "Extending Carbon Chain Length of 1-Butanol Pathway for 1-Hexanol Synthesis from Glucose by Engineered Escherichia coli." J Am Chem Soc 133(30);11399-401. PMID: 21707101

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

LYNEN: LYNEN F, OCHOA S "Enzymes of fatty acid metabolism." Biochim Biophys Acta 12(1-2);299-314. PMID: 13115439

STERN60: STERN JR, DRUMMOND GI, COON MJ, DEL CAMPILLO A (1960). "Enzymes of ketone body metabolism. I. Purification of an acetoacetate-synthesizing enzyme from ox liver." J Biol Chem 235;313-7. PMID: 13834445


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc11.