Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.14.13.21

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.14.13.21

Enzymes and Genes:
flavonoid 3'-monooxygenase Inferred from experiment : F3'HIIb ( Malus domestica )
flavonoid 3'-monooxygenase Inferred from experiment : F3'HI ( Malus domestica )

In Pathway: flavonol biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: flavonoid 3′-monooxygenase

Enzyme Commission Synonyms: flavonoid 3'-hydroxylase, flavonoid 3-hydroxylase (erroneous), NADPH:flavonoid-3'-hydroxylase, flavonoid 3-monooxygenase (erroneous)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -90.2616 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of flavonoids, including naringenin and (+)-dihydrokaempferol. Does not act on 4-coumarate or 4-coumaroyl-CoA.

Citations: [Hagmann83, Han10, Forkmann80]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R06538

Relationship Links: BRENDA:EC:1.14.13.21 , ENZYME:EC:1.14.13.21 , IUBMB-ExplorEnz:EC:1.14.13.21

Credits:
Created 08-Jul-2011 by Kothari A , SRI International


References

Forkmann80: Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana. Flavanone 3- and flavonoid 3'-hydroxylases." Z. Naturforsch. 35c, 691-695.

Hagmann83: Hagmann ML, Heller W, Grisebach H (1983). "Induction and characterization of a microsomal flavonoid 3'-hydroxylase from parsley cell cultures." Eur J Biochem 134(3);547-54. PMID: 6884346

Han10: Han Y, Vimolmangkang S, Soria-Guerra RE, Rosales-Mendoza S, Zheng D, Lygin AV, Korban SS (2010). "Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress." Plant Physiol 153(2);806-20. PMID: 20357139

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.