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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Malus domestica: flavonoid 3'-monooxygenaseInferred from experiment: F3'HI
flavonoid 3'-monooxygenaseInferred from experiment: F3'HIIb

In Pathway: flavonol biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: flavonoid 3′-monooxygenase

Enzyme Commission Synonyms: flavonoid 3'-hydroxylase, flavonoid 3-hydroxylase (erroneous), NADPH:flavonoid-3'-hydroxylase, flavonoid 3-monooxygenase (erroneous)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -91.90057Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on a number of flavonoids, including naringenin and (+)-dihydrokaempferol. Does not act on 4-coumarate or 4-coumaroyl-CoA.

Citations: [Hagmann83, Han10, Forkmann80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R06538

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 08-Jul-2011 by Kothari A, SRI International


Forkmann80: Forkmann G, Heller W, Grisebach H (1980). "Anthocyanin biosynthesis in flowers of Matthiola incana. Flavanone 3- and flavonoid 3'-hydroxylases." Z. Naturforsch. 35c, 691-695.

Hagmann83: Hagmann ML, Heller W, Grisebach H (1983). "Induction and characterization of a microsomal flavonoid 3'-hydroxylase from parsley cell cultures." Eur J Biochem 134(3);547-54. PMID: 6884346

Han10: Han Y, Vimolmangkang S, Soria-Guerra RE, Rosales-Mendoza S, Zheng D, Lygin AV, Korban SS (2010). "Ectopic expression of apple F3'H genes contributes to anthocyanin accumulation in the Arabidopsis tt7 mutant grown under nitrogen stress." Plant Physiol 153(2);806-20. PMID: 20357139

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed May 4, 2016, biocyc14.