MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: phospholipase A1Inferred from experiment: DAD1
phospholipase A1Inferred from experiment: AtLCAT3
acylhydrolaseInferred from experiment: DSEL

In Pathway: phospholipases, phosphatidylcholine acyl editing

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.03833Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme has a much broader specificity than EC phospholipase A2. Requires Ca2+.

Citations: [Kim11d, Gatt68, Scandella71, vandenBosch80, vandenBosch74]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a 1-monoglyceride + H2O → a fatty acid + glycerol + H+] (
i14: 1-oleoyl-sn-glycerol + H2O → glycerol + oleate + H+ (

Instance reactions of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (
i11: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O → 1-18:2-lysophosphatidylcholine + palmitate + H+ (

i12: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (

Unification Links: KEGG:R01314, Rhea:18689

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P0A921, UniProt:RELATED-TO:P18952, UniProt:RELATED-TO:P51528, UniProt:RELATED-TO:P53357, UniProt:RELATED-TO:Q9PMU8

Created 14-Jun-2011 by Dreher KA, PMN


Gatt68: Gatt S (1968). "Purification and properties of phospholipase A-1 from rat and calf brain." Biochim Biophys Acta 159(2);304-16. PMID: 5657461

Kim11d: Kim EY, Seo YS, Kim WT (2011). "AtDSEL, an Arabidopsis cytosolic DAD1-like acylhydrolase, is involved in negative regulation of storage oil mobilization during seedling establishment." J Plant Physiol. PMID: 21477884

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Scandella71: Scandella CJ, Kornberg A (1971). "A membrane-bound phospholipase A1 purified from Escherichia coli." Biochemistry 10(24);4447-56. PMID: 4946924

vandenBosch74: van den Bosch H, Aarsman AJ, van Deenen LL (1974). "Isolation and properties of a phospholipase A1 activity from beef pancreas." Biochim Biophys Acta 348(2);197-209. PMID: 4858811

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC14A.