Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.1.32

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.1.32

Enzymes and Genes:
acylhydrolase Inferred from experiment : DSEL ( Arabidopsis thaliana col )
phospholipase A1 Inferred from experiment : AtLCAT3 ( Arabidopsis thaliana col )
phospholipase A1 Inferred from experiment : DAD1 ( Arabidopsis thaliana col )

In Pathway: phospholipases , phosphatidylcholine acyl editing

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.03833 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+.

Citations: [Kim11b, Gatt68, Scandella71, vandenBosch80, vandenBosch74]

Gene-Reaction Schematic: ?

Instance reactions of [a phosphatidylcholine + H2O → a 2-lyso-phosphatidylcholine + a fatty acid + H+] (3.1.1.4):
i4: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O → 1-18:2-lysophosphatidylcholine + palmitate + H+ (3.1.1.32)

i5: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (3.1.1.4)

Instance reaction of [a 1-monoglyceride + H2O → a fatty acid + glycerol + H+] (3.1.1.23):
i7: 1-oleoylglycerol + H2O → glycerol + oleate + H+ (3.1.1.23)

Unification Links: KEGG:R01314 , Rhea:18689

Relationship Links: BRENDA:EC:3.1.1.32 , ENZYME:EC:3.1.1.32 , IUBMB-ExplorEnz:EC:3.1.1.32 , UniProt:RELATED-TO:P0A921 , UniProt:RELATED-TO:P18952 , UniProt:RELATED-TO:P51528 , UniProt:RELATED-TO:P53357 , UniProt:RELATED-TO:Q9PMU8

Credits:
Created 14-Jun-2011 by Dreher KA , PMN


References

Gatt68: Gatt S (1968). "Purification and properties of phospholipase A-1 from rat and calf brain." Biochim Biophys Acta 159(2);304-16. PMID: 5657461

Kim11b: Kim EY, Seo YS, Kim WT (2011). "AtDSEL, an Arabidopsis cytosolic DAD1-like acylhydrolase, is involved in negative regulation of storage oil mobilization during seedling establishment." J Plant Physiol. PMID: 21477884

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Scandella71: Scandella CJ, Kornberg A (1971). "A membrane-bound phospholipase A1 purified from Escherichia coli." Biochemistry 10(24);4447-56. PMID: 4946924

vandenBosch74: van den Bosch H, Aarsman AJ, van Deenen LL (1974). "Isolation and properties of a phospholipase A1 activity from beef pancreas." Biochim Biophys Acta 348(2);197-209. PMID: 4858811

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, biocyc12.