MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : phospholipase A1 Inferred from experiment : DAD1
phospholipase A1 Inferred from experiment : AtLCAT3
acylhydrolase Inferred from experiment : DSEL

In Pathway: phospholipases , phosphatidylcholine acyl editing

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phospholipase A1

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.03833 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This enzyme has a much broader specificity than EC phospholipase A2. Requires Ca2+.

Citations: [Kim11b, Gatt68, Scandella71, vandenBosch80, vandenBosch74]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a 1-monoglyceride + H2O → a fatty acid + glycerol + H+] (
i8: 1-oleoyl-sn-glycerol + H2O → glycerol + oleate + H+ (

Instance reactions of [a phosphatidylcholine + H2O → a 1-acyl 2-lyso-phosphatidylcholine + a long-chain fatty acid + H+] (
i5: 1,2-dipalmitoyl-phosphatidylcholine + H2O → 1-16:0-2-lysophosphatidylcholine + palmitate + H+ (

i6: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O → 1-18:2-lysophosphatidylcholine + palmitate + H+ (

Unification Links: KEGG:R01314 , Rhea:18689

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P0A921 , UniProt:RELATED-TO:P18952 , UniProt:RELATED-TO:P51528 , UniProt:RELATED-TO:P53357 , UniProt:RELATED-TO:Q9PMU8

Created 14-Jun-2011 by Dreher KA , PMN


Gatt68: Gatt S (1968). "Purification and properties of phospholipase A-1 from rat and calf brain." Biochim Biophys Acta 159(2);304-16. PMID: 5657461

Kim11b: Kim EY, Seo YS, Kim WT (2011). "AtDSEL, an Arabidopsis cytosolic DAD1-like acylhydrolase, is involved in negative regulation of storage oil mobilization during seedling establishment." J Plant Physiol. PMID: 21477884

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Scandella71: Scandella CJ, Kornberg A (1971). "A membrane-bound phospholipase A1 purified from Escherichia coli." Biochemistry 10(24);4447-56. PMID: 4946924

vandenBosch74: van den Bosch H, Aarsman AJ, van Deenen LL (1974). "Isolation and properties of a phospholipase A1 activity from beef pancreas." Biochim Biophys Acta 348(2);197-209. PMID: 4858811

vandenBosch80: van den Bosch H (1980). "Intracellular phospholipases A." Biochim Biophys Acta 604(2);191-246. PMID: 6252969

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc13.