Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Methylomonas sp. 16a: diapophytoene desaturaseInferred from experiment: crtN

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4,4′-diapophytoene desaturase (4,4′-diapolycopene-forming)

Enzyme Commission Synonyms: dehydrosqualene desaturase, CrtN, 4,4'-diapophytoene:FAD oxidoreductase

Taxonomic Range: Bacteria

15-cis-4,4'-diapophytoene + FAD + H+all-trans-4,4'-diapophytofluene + FADH2,
all-trans-4,4'-diapophytofluene + FAD + H+all-trans-4,4'-diapo-ζ-carotene + FADH2,
all-trans-4,4'-diapo-ζ-carotene + FAD + H+all-trans-4,4'-diaponeurosporene + FADH2,
all-trans-4,4'-diaponeurosporene + FAD + H+all-trans-4,4'-diapolycopene + FADH2

Standard Gibbs Free Energy (ΔrG in kcal/mol): -77.26233Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the bacterium Methylomonas sp. 16a, is responsible for four successive dehydrogenations. Some species possess a related enzyme that proceeds only as far as all-trans-4,4'-diaponeurosporene, cf. EC 1.3.8.o, 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming).

Citations: [Raisig01, Wieland94 , Tao05]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R09690, Rhea:31394

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 10-Mar-2011 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Raisig01: Raisig A, Sandmann G (2001). "Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways." Biochim Biophys Acta 1533(2);164-70. PMID: 11566453

Tao05: Tao L, Schenzle A, Odom JM, Cheng Q (2005). "Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde." Appl Environ Microbiol 71(6);3294-301. PMID: 15933032

Wieland94: Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Gotz F (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus." J Bacteriol 176(24);7719-26. PMID: 8002598

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc14.