Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.3.8.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.8.2

Enzymes and Genes:
diapophytoene desaturase Inferred from experiment : crtN ( Methylomonas sp. 16a )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4,4′-diapophytoene desaturase

Enzyme Commission Synonyms: dehydrosqualene desaturase, CrtN, 4,4'-diapophytoene:FAD oxidoreductase

Sub-reactions:
15-cis-4,4'-diapophytoene + FAD + H+all-trans-4,4'-diapophytofluene + FADH2 ,
all-trans-4,4'-diapophytofluene + FAD + H+all-trans-4,4'-diapo-ζ-carotene + FADH2 ,
all-trans-4,4'-diapo-ζ-carotene + FAD + H+all-trans-4,4'-diaponeurosporene + FADH2 ,
all-trans-4,4'-diaponeurosporene + FAD + H+all-trans-4,4'-diapolycopene + FADH2

Standard Gibbs Free Energy (ΔrG in kcal/mol): -77.26233 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the bacterium Methylomonas sp. 16a, is responsible for four successive dehydrogenations. Some species possess a related enzyme that proceeds only as far as all-trans-4,4'-diaponeurosporene, cf. EC 1.3.8.o, 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming).

Citations: [Raisig01, Wieland94, Tao05a]

Gene-Reaction Schematic: ?

Unification Links: Rhea:31394

Relationship Links: BRENDA:EC:1.3.8.2 , ENZYME:EC:1.3.8.2 , IUBMB-ExplorEnz:EC:1.3.8.2

Credits:
Created 10-Mar-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Raisig01: Raisig A, Sandmann G (2001). "Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways." Biochim Biophys Acta 1533(2);164-70. PMID: 11566453

Tao05a: Tao L, Schenzle A, Odom JM, Cheng Q (2005). "Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde." Appl Environ Microbiol 71(6);3294-301. PMID: 15933032

Wieland94: Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Gotz F (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus." J Bacteriol 176(24);7719-26. PMID: 8002598


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc14.