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MetaCyc Reaction: 1.3.8.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.8.2

Enzymes and Genes:

Methylomonas sp. 16a : diapophytoene desaturase Inferred from experiment : crtN

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 4,4′-diapophytoene desaturase

Enzyme Commission Synonyms: dehydrosqualene desaturase, CrtN, 4,4'-diapophytoene:FAD oxidoreductase

Taxonomic Range: Bacteria

Sub-reactions:
15-cis-4,4'-diapophytoene + FAD + H+all-trans-4,4'-diapophytofluene + FADH2 ,
all-trans-4,4'-diapophytofluene + FAD + H+all-trans-4,4'-diapo-ζ-carotene + FADH2 ,
all-trans-4,4'-diapo-ζ-carotene + FAD + H+all-trans-4,4'-diaponeurosporene + FADH2 ,
all-trans-4,4'-diaponeurosporene + FAD + H+all-trans-4,4'-diapolycopene + FADH2

Standard Gibbs Free Energy (ΔrG in kcal/mol): -77.26233 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme, characterized from the bacterium Methylomonas sp. 16a, is responsible for four successive dehydrogenations. Some species possess a related enzyme that proceeds only as far as all-trans-4,4'-diaponeurosporene, cf. EC 1.3.8.o, 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming).

Citations: [Raisig01, Wieland94, Tao05a]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:31394

Relationship Links: BRENDA:EC:1.3.8.2 , ENZYME:EC:1.3.8.2 , IUBMB-ExplorEnz:EC:1.3.8.2

Credits:
Created 10-Mar-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Raisig01: Raisig A, Sandmann G (2001). "Functional properties of diapophytoene and related desaturases of C(30) and C(40) carotenoid biosynthetic pathways." Biochim Biophys Acta 1533(2);164-70. PMID: 11566453

Tao05a: Tao L, Schenzle A, Odom JM, Cheng Q (2005). "Novel carotenoid oxidase involved in biosynthesis of 4,4'-diapolycopene dialdehyde." Appl Environ Microbiol 71(6);3294-301. PMID: 15933032

Wieland94: Wieland B, Feil C, Gloria-Maercker E, Thumm G, Lechner M, Bravo JM, Poralla K, Gotz F (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus." J Bacteriol 176(24);7719-26. PMID: 8002598


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Apr 21, 2015, BIOCYC13B.