|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
nucleoside diphosphate phosphatase ( Allium cepa )
nucleoside diphosphate phosphatase ( Pisum sativum )
nucleoside triphosphate phosphohydrolase : ytkD ( Bacillus subtilis subtilis 168 )
apyrase : YND1 ( Saccharomyces cerevisiae )
ectonucleoside triphosphate diphosphohydrolase 1 : ENTPD1 ( Homo sapiens )
apyrase ( Pisum sativum )
ectonucleoside triphosphate diphosphohydrolase 4 : ENTPD4 ( Homo sapiens )
18.104.22.168: UTP + 2 H2O → UMP + 2 phosphate + 2 H+
In Pathway: UTP and CTP dephosphorylation I
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nucleoside diphosphate phosphatase
Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -6.8129883 [Latendresse13]
Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.
Instance reaction of [a nucleoside diphosphate + H2O = a nucleoside 5'-monophosphate + phosphate + H+] (22.214.171.124):
i1: UDP + H2O → UMP + phosphate + H+ (126.96.36.199)
Unification Links: KEGG:R00155
Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635
Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851
Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856
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