MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Allium cepa : nucleoside diphosphate phosphatase Inferred from experiment
Bacillus subtilis subtilis 168 : nucleoside triphosphate phosphohydrolase : ytkD
Homo sapiens : ectonucleoside triphosphate diphosphohydrolase 4 : ENTPD4
ectonucleoside triphosphate diphosphohydrolase 1 : ENTPD1
Pisum sativum : nucleoside diphosphate phosphatase Inferred from experiment
Saccharomyces cerevisiae : apyrase : YND1

Sub-reaction of: UTP + 2 H2O → UMP + 2 phosphate + 2 H+

In Pathway: UTP and CTP dephosphorylation I

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside diphosphate phosphatase

Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.8129883 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.

Citations: [Uccelletti04, Failer02, Yeung00, Gibson55]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [a nucleoside diphosphate + H2O = a nucleoside 5'-monophosphate + phosphate + H+] (
i1: UDP + H2O → UMP + phosphate + H+ (

Unification Links: KEGG:R00155

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:

Created 28-Feb-2011 by Zhang P , TAIR


Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635

Gibson55: Gibson DM, Ayengar P, Sanadi DR (1955). "A phosphatase specific for nucleoside diphosphates." Biochim Biophys Acta 16(4);536-8. PMID: 14389272

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851

Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, biocyc13.