MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Allium cepa: nucleoside diphosphate phosphataseInferred from experiment
Bacillus subtilis subtilis 168: nucleoside triphosphate phosphohydrolase: ytkD
Homo sapiens: ectonucleoside triphosphate diphosphohydrolase 4: ENTPD4
ectonucleoside triphosphate diphosphohydrolase 1: ENTPD1
Pisum sativum: nucleoside diphosphate phosphataseInferred from experiment
Saccharomyces cerevisiae: apyrase: YND1

Sub-reaction of: UTP + 2 H2O → UMP + 2 phosphate + 2 H+

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside diphosphate phosphatase

Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.8129883Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.

Citations: [Uccelletti04, Failer02, Yeung00, Gibson55]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a nucleoside diphosphate + H2O = a nucleoside 5'-monophosphate + phosphate + H+] (
i1: UDP + H2O → UMP + phosphate + H+ (

Unification Links: KEGG:R00155

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 28-Feb-2011 by Zhang P, TAIR


Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635

Gibson55: Gibson DM, Ayengar P, Sanadi DR (1955). "A phosphatase specific for nucleoside diphosphates." Biochim Biophys Acta 16(4);536-8. PMID: 14389272

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851

Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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