|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Allium cepa:||nucleoside diphosphate phosphatase|
|Bacillus subtilis subtilis 168:||nucleoside triphosphate phosphohydrolase: ytkD|
|Homo sapiens:||ectonucleoside triphosphate diphosphohydrolase 4: ENTPD4|
ectonucleoside triphosphate diphosphohydrolase 1: ENTPD1
|Pisum sativum:||nucleoside diphosphate phosphatase|
|Saccharomyces cerevisiae:||apyrase: YND1|
22.214.171.124: UTP + 2 H2O → UMP + 2 phosphate + 2 H+
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nucleoside diphosphate phosphatase
Enzyme Commission Synonyms: nucleoside-diphosphatase, thiaminpyrophosphatase, UDPase, inosine diphosphatase, adenosine diphosphatase, IDPase, ADPase, adenosinepyrophosphatase, guanosine diphosphatase, guanosine 5'-diphosphatase, inosine 5'-diphosphatase, uridine diphosphatase, uridine 5'-diphosphatase, type B nucleoside diphosphatase, GDPase, CDPase, nucleoside 5'-diphosphatase, type L nucleoside diphosphatase, NDPase, nucleoside diphosphate phosphohydrolase
Standard Gibbs Free Energy (ΔrG'°): -6.8129883 kcal/mol [Latendresse13]
Enzyme Commission Summary:
Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate, but not on ADP.
Unification Links: KEGG:R00155
Failer02: Failer BU, Braun N, Zimmermann H (2002). "Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase." J Biol Chem 277(40);36978-86. PMID: 12167635
Uccelletti04: Uccelletti D, O'Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB (2004). "ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans." J Biol Chem 279(26);27390-8. PMID: 15102851
Yeung00: Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart." Biochemistry 39(42);12916-23. PMID: 11041856
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