Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 4.1.3.41

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.3.41

Enzymes and Genes:
D 3-hydroxyaspartate aldolase Inferred from experiment : dhaa ( Paracoccus denitrificans IFO 13301 )

Reaction Locations: cytosol

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxy-D-aspartate aldolase

Enzyme Commission Synonyms: D-3-hydroxyaspartate aldolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.1899872 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the α-position of the substrate, but accepts both the threo and erythro forms at the β-position. The erythro form is a far better substrate (about 100 fold). The enzyme can also accept D-allothreonine, D-threonine, D-erythro-3-phenylserine and D-threo-3-phenylserine. Different from EC 4.1.3.14, L-erythro-3-hydroxyaspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.

Citations: [Liu03]

Gene-Reaction Schematic: ?

Unification Links: Rhea:27934

Relationship Links: BRENDA:EC:4.1.3.41 , ENZYME:EC:4.1.3.41 , IUBMB-ExplorEnz:EC:4.1.3.41

Credits:
Created 14-Oct-2010 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Liu03: Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S (2003). "A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning." Appl Microbiol Biotechnol 62(1);53-60. PMID: 12835921


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, BIOCYC13A.