|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Paracoccus denitrificans IFO 13301 :||D 3-hydroxyaspartate aldolase
Reaction Locations: cytosol
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 3-hydroxy-D-aspartate aldolase
Enzyme Commission Synonyms: D-3-hydroxyaspartate aldolase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 3.1899872 [Latendresse13]
Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the α-position of the substrate, but accepts both the threo and erythro forms at the β-position. The erythro form is a far better substrate (about 100 fold). The enzyme can also accept D-allothreonine, D-threonine, D-erythro-3-phenylserine and D-threo-3-phenylserine. Different from EC 22.214.171.124, L-erythro-3-hydroxyaspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.
Unification Links: Rhea:27934
Liu03b: Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S (2003). "A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning." Appl Microbiol Biotechnol 62(1);53-60. PMID: 12835921
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