MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Paracoccus denitrificans IFO 13301: D 3-hydroxyaspartate aldolaseInferred from experiment: dhaa

Reaction Locations: cytosol

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3-hydroxy-D-aspartate aldolase

Enzyme Commission Synonyms: D-3-hydroxyaspartate aldolase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 3.1899872Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the α-position of the substrate, but accepts both the threo and erythro forms at the β-position. The erythro form is a far better substrate (about 100 fold). The enzyme can also accept D-allothreonine, D-threonine, D-erythro-3-phenylserine and D-threo-3-phenylserine. Different from EC, L-erythro-3-hydroxyaspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.

Citations: [Liu03a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:27934

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 14-Oct-2010 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Liu03a: Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S (2003). "A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning." Appl Microbiol Biotechnol 62(1);53-60. PMID: 12835921

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13A.