Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.3.8.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.3.8.7

Enzymes and Genes:
medium-chain acyl-CoA dehydrogenase Inferred from experiment : ACADM ( Homo sapiens )

Supersedes EC numbers: 1.3.2.2, 1.3.99.3

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: The left side is missing: H: 1

Enzyme Commission Primary Name: medium-chain acyl-CoA dehydrogenase

Enzyme Commission Synonyms: fatty acyl coenzyme A dehydrogenase (ambiguous), acyl coenzyme A dehydrogenase (ambiguous), acyl dehydrogenase (ambiguous), fatty-acyl-CoA dehydrogenase (ambiguous), acyl CoA dehydrogenase (ambiguous), general acyl CoA dehydrogenase (ambiguous), medium-chain acyl-coenzyme A dehydrogenase, acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous), ACADM (gene name).

Standard Gibbs Free Energy (ΔrG in kcal/mol): 42.211 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C8 to C12 compounds [CRANE56]. The enzyme from rat does not accept C16 at all and is most active with C6-C8 compounds [Ikeda85]. cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.

Citations: [Thorpe95, Crane55, Kim93b, Peterson95, Toogood04]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.3.8.7 , ENZYME:EC:1.3.8.7 , IUBMB-ExplorEnz:EC:1.3.8.7

Credits:
Revised 06-Jan-2011 by Caspi R , SRI International


References

Crane55: Crane FL, Hauge JG, Beinert H (1955). "Flavoproteins involved in the first oxidative step of the fatty acid cycle." Biochim Biophys Acta 17(2);292-4. PMID: 13239683

CRANE56: Crane FL, Mii S, Hauge JG, Green DE, Beinert H (1956). "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase." J Biol Chem 218(2);701-6. PMID: 13295224

Ikeda85: Ikeda Y, Okamura-Ikeda K, Tanaka K (1985). "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme." J Biol Chem 260(2);1311-25. PMID: 3968063

Kim93b: Kim JJ, Wang M, Paschke R (1993). "Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate." Proc Natl Acad Sci U S A 90(16);7523-7. PMID: 8356049

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Peterson95: Peterson KL, Sergienko EE, Wu Y, Kumar NR, Strauss AW, Oleson AE, Muhonen WW, Shabb JB, Srivastava DK (1995). "Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules." Biochemistry 34(45);14942-53. PMID: 7578106

Thorpe95: Thorpe C, Kim JJ (1995). "Structure and mechanism of action of the acyl-CoA dehydrogenases." FASEB J 9(9);718-25. PMID: 7601336

Toogood04: Toogood HS, van Thiel A, Basran J, Sutcliffe MJ, Scrutton NS, Leys D (2004). "Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex." J Biol Chem 279(31);32904-12. PMID: 15159392


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc13.