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MetaCyc Reaction: 1.1.1.391

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.1.1.391

Enzymes and Genes:

Blautia producta K 2/25.1: NAD-dependent bile acid 3β-dehydrogenaseInferred from experiment
Clostridium innocuum D1144/3: NAD-dependent bile acid 3β-dehydrogenaseInferred from experiment
Eggerthella lenta DSM 2243: NAD-dependent bile acid 3β-dehydrogenaseInferred from experiment: Elen_0198

In Pathway: glycocholate metabolism (bacteria)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 3β-hydroxycholanate 3-dehydrogenase (NAD+)

Enzyme Commission Synonyms: 3β-hydroxysteroid dehydrogenase

Standard Gibbs Free Energy (ΔrG): 0.37820435 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase, in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. c.f. EC 1.1.1.393, 3β-hydroxysteroid dehydrogenase (NADP+).

Citations: [Ridlon06, Edenharder89, Edenharder89a, Devlin15]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:1.1.1.391, ENZYME:EC:1.1.1.391, IUBMB-ExplorEnz:EC:1.1.1.391

Credits:
Created 02-Jun-2010 by Fulcher CA, SRI International


References

Devlin15: Devlin AS, Fischbach MA (2015). "A biosynthetic pathway for a prominent class of microbiota-derived bile acids." Nat Chem Biol 11(9);685-90. PMID: 26192599

Edenharder89: Edenharder R, Pfutzner A, Hammann R (1989). "Characterization of NAD-dependent 3 alpha- and 3 beta-hydroxysteroid dehydrogenase and of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus." Biochim Biophys Acta 1004(2);230-8. PMID: 2752021

Edenharder89a: Edenharder R, Pfutzner M (1989). "Partial purification and characterization of an NAD-dependent 3 beta-hydroxysteroid dehydrogenase from Clostridium innocuum." Appl Environ Microbiol 55(6);1656-9. PMID: 2764572

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Ridlon06: Ridlon JM, Kang DJ, Hylemon PB (2006). "Bile salt biotransformations by human intestinal bacteria." J Lipid Res 47(2);241-59. PMID: 16299351


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC13.