Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.201

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.201

Enzymes and Genes:
7β-hydroxysteroid dehydrogenase Inferred from experiment ( Blautia producta K 2/25.1 )

In Pathway: glycocholate metabolism (bacteria)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 7β-hydroxysteroid dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-dependent 7β-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.6264954 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Catalyses the oxidation of the 7β-hydroxy group of bile acids such as ursodeoxycholate.

Citations: [Ridlon06, Hirano82, MacDonald81, MacDonald82]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.1.1.201 , ENZYME:EC:1.1.1.201 , IUBMB-ExplorEnz:EC:1.1.1.201

Credits:
Created 02-Jun-2010 by Fulcher CA , SRI International


References

Hirano82: Hirano S, Masuda N (1982). "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens." Appl Environ Microbiol 43(5);1057-63. PMID: 6954878

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MacDonald81: MacDonald IA, Roach PD (1981). "Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum." Biochim Biophys Acta 665(2);262-9. PMID: 6945134

MacDonald82: MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV (1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms." Appl Environ Microbiol 44(5);1187-95. PMID: 6758698

Ridlon06: Ridlon JM, Kang DJ, Hylemon PB (2006). "Bile salt biotransformations by human intestinal bacteria." J Lipid Res 47(2);241-59. PMID: 16299351


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, BIOCYC14B.