Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.1.1.201

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.201

Enzymes and Genes:
7β-hydroxysteroid dehydrogenase Inferred from experiment ( Blautia producta K 2/25.1 )

In Pathway: glycocholate metabolism (bacteria)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 7β-hydroxysteroid dehydrogenase (NADP+)

Enzyme Commission Synonyms: NADP-dependent 7β-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase (NADP)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.6264954 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Catalyses the oxidation of the 7β-hydroxy group of bile acids such as ursodeoxycholate.

Citations: [Ridlon06, Hirano82, MacDonald81, MacDonald82]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.1.1.201 , ENZYME:EC:1.1.1.201 , IUBMB-ExplorEnz:EC:1.1.1.201

Credits:
Created 02-Jun-2010 by Fulcher CA , SRI International


References

Hirano82: Hirano S, Masuda N (1982). "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens." Appl Environ Microbiol 43(5);1057-63. PMID: 6954878

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MacDonald81: MacDonald IA, Roach PD (1981). "Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum." Biochim Biophys Acta 665(2);262-9. PMID: 6945134

MacDonald82: MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV (1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms." Appl Environ Microbiol 44(5);1187-95. PMID: 6758698

Ridlon06: Ridlon JM, Kang DJ, Hylemon PB (2006). "Bile salt biotransformations by human intestinal bacteria." J Lipid Res 47(2);241-59. PMID: 16299351


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, BIOCYC13B.