|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: glycocholate metabolism (bacteria)
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 7β-hydroxysteroid dehydrogenase (NADP+)
Enzyme Commission Synonyms: NADP-dependent 7β-hydroxysteroid dehydrogenase, 7β-hydroxysteroid dehydrogenase (NADP)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.6264954 [Latendresse13]
Enzyme Commission Summary:
Catalyses the oxidation of the 7β-hydroxy group of bile acids such as ursodeoxycholate.
Hirano82: Hirano S, Masuda N (1982). "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens." Appl Environ Microbiol 43(5);1057-63. PMID: 6954878
MacDonald82: MacDonald IA, Rochon YP, Hutchison DM, Holdeman LV (1982). "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms." Appl Environ Microbiol 44(5);1187-95. PMID: 6758698
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