Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.4.3.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.4.3.4

Enzymes and Genes:
monoamine oxidase A Inferred from experiment : Maoa ( Rattus norvegicus )

In Pathway: noradrenaline and adrenaline degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: monoamine oxidase

Enzyme Commission Synonyms: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.962988 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [Edmondson04]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.

Citations: [Dostert, Shih04, Tipton04, De05, Youdim06, Youdim06a]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02532

Relationship Links: BRENDA:EC:1.4.3.4 , ENZYME:EC:1.4.3.4 , IUBMB-ExplorEnz:EC:1.4.3.4

Credits:
Created 30-Sep-2009 by Fulcher CA , SRI International


References

De05: De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A (2005). "Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B." Proc Natl Acad Sci U S A 102(36);12684-9. PMID: 16129825

Dostert: Dostert PL, Strolin Benedetti M, Tipton KF "Interactions of monoamine oxidase with substrates and inhibitors." Med Res Rev 9(1);45-89. PMID: 2644497

Edmondson04: Edmondson DE, Mattevi A, Binda C, Li M, Hubalek F (2004). "Structure and mechanism of monoamine oxidase." Curr Med Chem 11(15);1983-93. PMID: 15279562

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Shih04: Shih JC, Chen K (2004). "Regulation of MAO-A and MAO-B gene expression." Curr Med Chem 11(15);1995-2005. PMID: 15279563

Tipton04: Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J (2004). "Monoamine oxidases: certainties and uncertainties." Curr Med Chem 11(15);1965-82. PMID: 15279561

Youdim06: Youdim MB, Edmondson D, Tipton KF (2006). "The therapeutic potential of monoamine oxidase inhibitors." Nat Rev Neurosci 7(4);295-309. PMID: 16552415

Youdim06a: Youdim MB, Bakhle YS (2006). "Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness." Br J Pharmacol 147 Suppl 1;S287-96. PMID: 16402116


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.