Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.4.3.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.4.3.4

Enzymes and Genes:
monoamine oxidase A Inferred from experiment : Maoa ( Rattus norvegicus )

In Pathway: noradrenaline and adrenaline degradation

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: monoamine oxidase

Enzyme Commission Synonyms: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.962988 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A mitochondrial outer-membrane flavoprotein (FAD) that catalyses the oxidative deamination of neurotransmitters and biogenic amines [Edmondson04]. Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC 1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. This enzyme is inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22 (diamine oxidase), it is not inhibited by semicarbazide.

Citations: [Dostert, Shih04, Tipton04, De05, Youdim06, Youdim06a]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02532

Relationship Links: BRENDA:EC:1.4.3.4 , ENZYME:EC:1.4.3.4 , IUBMB-ExplorEnz:EC:1.4.3.4

Credits:
Created 30-Sep-2009 by Fulcher CA , SRI International


References

De05: De Colibus L, Li M, Binda C, Lustig A, Edmondson DE, Mattevi A (2005). "Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B." Proc Natl Acad Sci U S A 102(36);12684-9. PMID: 16129825

Dostert: Dostert PL, Strolin Benedetti M, Tipton KF "Interactions of monoamine oxidase with substrates and inhibitors." Med Res Rev 9(1);45-89. PMID: 2644497

Edmondson04: Edmondson DE, Mattevi A, Binda C, Li M, Hubalek F (2004). "Structure and mechanism of monoamine oxidase." Curr Med Chem 11(15);1983-93. PMID: 15279562

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Shih04: Shih JC, Chen K (2004). "Regulation of MAO-A and MAO-B gene expression." Curr Med Chem 11(15);1995-2005. PMID: 15279563

Tipton04: Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J (2004). "Monoamine oxidases: certainties and uncertainties." Curr Med Chem 11(15);1965-82. PMID: 15279561

Youdim06: Youdim MB, Edmondson D, Tipton KF (2006). "The therapeutic potential of monoamine oxidase inhibitors." Nat Rev Neurosci 7(4);295-309. PMID: 16552415

Youdim06a: Youdim MB, Bakhle YS (2006). "Monoamine oxidase: isoforms and inhibitors in Parkinson's disease and depressive illness." Br J Pharmacol 147 Suppl 1;S287-96. PMID: 16402116


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc12.