|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Polynucleotide-Reactions → RNA-Reactions → tRNA-Reactions → tRNA-Charging-Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Methanocaldococcus jannaschii:||O-phosphoseryl-tRNA ligase: sepS|
In Pathway: L-cysteine biosynthesis II (tRNA-dependent)
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: O-phospho-L-serine—tRNA ligase
Enzyme Commission Synonyms: O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -61.770264 [Latendresse13]
Enzyme Commission Summary:
In organisms like Archaeoglobus fulgidus lacking EC 126.96.36.199 (canonical cysteinyl-tRNA synthetase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which O-phosphoseryl-tRNA ligase ligates the noncanonical amino acid O-phosphoserine to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism [Fukunaga07]. Methanosarcina mazei can use both pathways, the canonical route using EC 188.8.131.52 and the indirect pathway [Hauenstein08].
Unification Links: KEGG:R08576
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