MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

In Pathway: thyroid hormone metabolism II (via conjugation and/or degradation)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

Standard Gibbs Free Energy (ΔrG in kcal/mol): -40.226536Inferred by computational analysis [Latendresse13]

This reaction has been postulated to involve either transamination, or oxidative deamination, with the latter mechanism more likely (reviewed in [Wu05b]).


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Wu05b: Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ (2005). "Alternate pathways of thyroid hormone metabolism." Thyroid 15(8);943-58. PMID: 16131336

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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