|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens :||UDP-glucuronosyltransferase 1-8
Supersedes EC numbers: 18.104.22.168, 22.214.171.124
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glucuronosyltransferase
Enzyme Commission Synonyms: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17β-hydroxysteroid UDP-glucuronosyltransferase, 3α-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 8.145813 [Latendresse13]
Enzyme Commission Summary:
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 126.96.36.199, EC 188.8.131.52, EC 184.108.40.206, EC 220.127.116.11, EC 18.104.22.168, EC 22.214.171.124, EC 126.96.36.199 and EC 188.8.131.52. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in [Bock83].
Bock79: Bock KW, Josting D, Lilienblum W, Pfeil H (1979). "Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital." Eur J Biochem 98(1);19-26. PMID: 111930
Bock83: Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR (1983). "UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions." Biochem Pharmacol 32(6);953-5. PMID: 6404284
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