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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
UDP-glucuronosyltransferase 1-8 Inferred from experiment : UGT1A8 ( Homo sapiens )

In Pathway: thyroid hormone metabolism II (via conjugation and/or degradation)

Supersedes EC numbers:,

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucuronosyltransferase

Enzyme Commission Synonyms: 1-naphthol glucuronyltransferase, 1-naphthol-UDP-glucuronosyltransferase, 17β-hydroxysteroid UDP-glucuronosyltransferase, 3α-hydroxysteroid UDP-glucuronosyltransferase, 4-hydroxybiphenyl UDP-glucuronosyltransferase, 4-methylumbelliferone UDP-glucuronosyltransferase, 4-nitrophenol UDP-glucuronyltransferase, 4-nitrophenol UDPGT, 17-OH steroid UDPGT, 3-OH androgenic UDPGT, bilirubin uridine diphosphoglucuronyltransferase, bilirubin UDP-glucuronosyltransferase, bilirubin monoglucuronide glucuronyltransferase, bilirubin UDPGT, bilirubin glucuronyltransferase, ciramadol UDP-glucuronyltransferase, estriol UDP-glucuronosyltransferase, estrone UDP-glucuronosyltransferase, uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase, uridine diphosphoglucuronate-estriol glucuronosyltransferase, uridine diphosphoglucuronate-estradiol glucuronosyltransferase, uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase, uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase, uridine diphosphoglucuronate-estriol 16α-glucuronosyltransferase, GT, morphine glucuronyltransferase, p-hydroxybiphenyl UDP glucuronyltransferase, p-nitrophenol UDP-glucuronosyltransferase, p-nitrophenol UDP-glucuronyltransferase, p-nitrophenylglucuronosyltransferase, p-phenylphenol glucuronyltransferase, phenyl-UDP-glucuronosyltransferase, PNP-UDPGT, UDP glucuronate-estradiol-glucuronosyltransferase, UDP glucuronosyltransferase, UDP glucuronate-estriol glucuronosyltransferase, UDP glucuronic acid transferase, UDP glucuronyltransferase, UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase, UDP-glucuronate-bilirubin glucuronyltransferase, UDP-glucuronosyltransferase, UDP-glucuronyltransferase, UDPGA transferase, UDPGA-glucuronyltransferase, UDPGT, uridine diphosphoglucuronyltransferase, uridine diphosphoglucuronate-bilirubin glucuronosyltransferase, uridine diphosphate glucuronyltransferase, uridine 5'-diphosphoglucuronyltransferase, uridine diphosphoglucuronosyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 8.145813 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC, EC, EC, EC, EC, EC, EC and EC A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in [Bock83].

Citations: [Bock79, Green85, Burchell81, Dutton80, Jansen74]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Bock79: Bock KW, Josting D, Lilienblum W, Pfeil H (1979). "Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital." Eur J Biochem 98(1);19-26. PMID: 111930

Bock83: Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR (1983). "UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions." Biochem Pharmacol 32(6);953-5. PMID: 6404284

Burchell81: Burchell B (1981). "Identification and purification of multiple forms of UDP-glucuronosyltransferase." Rev. Biochem. Toxicol. 3 132.

Dutton80: Dutton GJ (1980). "Glucuronidation of Drugs and Other Compounds." C.R.C. Press, Boca Raton, Florida.

Green85: Green MD, Falany CN, Kirkpatrick RB, Tephly TR (1985). "Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase." Biochem J 230(2);403-9. PMID: 3931633

Jansen74: Jansen PLM (1974). "The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes." Biochim. Biophys. Acta 338 170-182.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 28, 2014, BIOCYC15B.