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MetaCyc Reaction: 6.5.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Macromolecule Reactions Polynucleotide-Reactions RNA-Reactions

EC Number: 6.5.1.4

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : RNA 3'-terminal phosphate cyclase Inferred from experiment : rtcA

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: RNA 3′-terminal-phosphate cyclase (ATP)

Enzyme Commission Synonyms: RNA cyclase (ambiguous), RNA-3'-phosphate cyclase (ambiguous)

Taxonomic Range: Archaea , Metazoa , Bacteria

Enzyme Commission Summary:
Adenosine 5′-(γ-thio)triphosphate can act instead of ATP. cf. EC 6.5.1.5, RNA 3′-terminal-phosphate cyclase (GTP).

Citations: [Reinberg85, Filipowicz83]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:6.5.1.4 , ENZYME:EC:6.5.1.4 , IUBMB-ExplorEnz:EC:6.5.1.4 , UniProt:RELATED-TO:O00442 , UniProt:RELATED-TO:Q9V0Z6


References

Filipowicz83: Filipowicz W, Konarska M, Gross HJ, Shatkin AJ (1983). "RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract." Nucleic Acids Res 11(5);1405-18. PMID: 6828385

Reinberg85: Reinberg D, Arenas J, Hurwitz J (1985). "The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives." J Biol Chem 260(10);6088-97. PMID: 2581947


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Jul 30, 2015, biocyc13.