|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
In Pathway: nicotinate degradation I
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nicotinate dehydrogenase (cytochrome)
Enzyme Commission Synonyms: nicotinic acid hydroxylase, nicotinate hydroxylase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -4.349472 [Latendresse13]
Enzyme Commission Summary:
This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family. While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase. The small subunit contains a typical molybdopterin cytosine dinucleotide(MCD) cofactor and two [2Fe-2S] clusters [Jimenez08].
Jimenez08: Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E (2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440." Proc Natl Acad Sci U S A 105(32);11329-34. PMID: 18678916
Yang09: Yang Y, Yuan S, Chen T, Ma P, Shang G, Dai Y (2009). "Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440." Biodegradation 20(4);541-9. PMID: 19118407
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