Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
twitter

MetaCyc Reaction: 1.17.2.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.17.2.1

Enzymes and Genes:
nicotinate dehydrogenase (cytochrome) Inferred from experiment : nicB , nicA ( Pseudomonas putida KT2440 )
nicotinate dehydrogenase (cytochrome) Inferred from experiment ( Pseudomonas fluorescens TN5 )

In Pathway: nicotinate degradation I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: nicotinate dehydrogenase (cytochrome)

Enzyme Commission Synonyms: nicotinic acid hydroxylase, nicotinate hydroxylase

Enzyme Commission Summary:
This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family. While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase. The small subunit contains a typical molybdopterin cytosine dinucleotide(MCD) cofactor and two [2Fe-2S] clusters [Jimenez08].

Citations: [Yang09a]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.17.2.1 , ENZYME:EC:1.17.2.1 , IUBMB-ExplorEnz:EC:1.17.2.1

Credits:
Revised 22-Aug-2012 by Caspi R , SRI International


References

Jimenez08: Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E (2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440." Proc Natl Acad Sci U S A 105(32);11329-34. PMID: 18678916

Yang09a: Yang Y, Yuan S, Chen T, Ma P, Shang G, Dai Y (2009). "Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440." Biodegradation 20(4);541-9. PMID: 19118407


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Dec 20, 2014, BIOCYC14A.