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available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Pseudomonas fluorescens TN5: nicotinate dehydrogenase (cytochrome)Inferred from experiment
Pseudomonas putida KT2440: nicotinate dehydrogenase (cytochrome)Inferred from experiment: nicB, nicA

In Pathway: nicotinate degradation I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nicotinate dehydrogenase (cytochrome)

Enzyme Commission Synonyms: nicotinic acid hydroxylase, nicotinate hydroxylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.349472Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases, but differs from most other members of this family. While most members contain an FAD cofactor, the large subunit of this enzyme contains three c-type cytochromes, enabling it to interact with the electron transfer chain, probably by delivering the electrons to a cytochrome oxidase. The small subunit contains a typical cytidylyl molybdenum cofactor (MCD) and two [2Fe-2S] clusters [Jimenez08].

Citations: [Yang09]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 22-Aug-2012 by Caspi R, SRI International


Jimenez08: Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E (2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440." Proc Natl Acad Sci U S A 105(32);11329-34. PMID: 18678916

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Yang09: Yang Y, Yuan S, Chen T, Ma P, Shang G, Dai Y (2009). "Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440." Biodegradation 20(4);541-9. PMID: 19118407

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc14.