MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: D-mannonate oxidoreductaseInferred from experiment: uxuB
Thermotoga maritima: D-mannonate dehydrogenaseInferred from experiment: uxuB

In Pathway: D-fructuronate degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: fructuronate reductase

Enzyme Commission Synonyms: mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, D-mannonate:NAD oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.0817871Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also reduces D-tagaturonate.

Citations: [Hickman60, Kilgore59]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02454, Rhea:15729

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P33029, UniProt:RELATED-TO:P39160, UniProt:RELATED-TO:P77260, UniProt:RELATED-TO:Q9CF49


Hickman60: Hickman J, Ashwell G (1960). "Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli." J Biol Chem 235;1566-70. PMID: 14401695

Kilgore59: Kilgore WW, Starr MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora." J Biol Chem 234;2227-35. PMID: 14409051

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu Nov 26, 2015, biocyc14.