Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.57

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.57

Enzymes and Genes:
D-mannonate oxidoreductase Inferred from experiment : uxuB ( Escherichia coli K-12 substr. MG1655 )
D-mannonate dehydrogenase Inferred from experiment : uxuB ( Thermotoga maritima )

In Pathway: D-fructuronate degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: fructuronate reductase

Enzyme Commission Synonyms: mannonate oxidoreductase, mannonic dehydrogenase, D-mannonate dehydrogenase, D-mannonate:NAD oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.0817871 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also reduces D-tagaturonate.

Citations: [Hickman60, KILGORE59]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02454 , Rhea:15729

Relationship Links: BRENDA:EC:1.1.1.57 , ENZYME:EC:1.1.1.57 , IUBMB-ExplorEnz:EC:1.1.1.57 , UniProt:RELATED-TO:P33029 , UniProt:RELATED-TO:P39160 , UniProt:RELATED-TO:P77260 , UniProt:RELATED-TO:Q9CF49


References

Hickman60: Hickman J, Ashwell G (1960). "Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli." J Biol Chem 235;1566-70. PMID: 14401695

KILGORE59: KILGORE WW, STARR MP (1959). "Catabolism of galacturonic and glucuronic acids by Erwinia carotovora." J Biol Chem 234;2227-35. PMID: 14409051

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc11.