MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
tributyrin + H2O → 1,2-dibutyrin + butanoate + H+ (

Enzyme Commission Primary Name: lipoprotein lipase

Enzyme Commission Synonyms: clearing factor lipase, diacylglycerol lipase, postheparin esterase, diglyceride lipase, postheparin lipase, diacylglycerol hydrolase, lipemia-clearing factor

Taxonomic Range: Metazoa

Standard Gibbs Free Energy (ΔrG): -13.038254 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

Citations: [Egelrud73, Fielding70, Greten70, Morley72, NilssonEhle71]

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Imported from HumanCyc 02-Oct-2014 by Caspi R, SRI International


Egelrud73: Egelrud T, Olivecrona T (1973). "Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors." Biochim Biophys Acta 306(1);115-27. PMID: 4703566

Fielding70: Fielding CJ (1970). "Human lipoprotein lipase. I. Purification and substrate specificity." Biochim Biophys Acta 206(1);109-17. PMID: 5441398

Greten70: Greten H, Levy RI, Fales H, Fredrickson DS (1970). "Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase"." Biochim Biophys Acta 210(1);39-45. PMID: 5466051

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Morley72: Morley N, Kuksis A (1972). "Positional specificity of lipoprotein lipase." J Biol Chem 247(20);6389-93. PMID: 5076762

NilssonEhle71: Nilsson-Ehle P, Belfrage P, Borgstrom B (1971). "Purified human lipoprotein lipase: positional specificity." Biochim Biophys Acta 248(1);114-20. PMID: 5168777

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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