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available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: leucyl, phenylalanyl-tRNA-protein transferaseInferred from experiment: aat

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: leucyltransferase

Enzyme Commission Synonyms: leucyl, phenylalanine-tRNA-protein transferase, leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase, leucyl-phenylalanine-transfer ribonucleate-protein transferase, L-leucyl-tRNA:protein leucyltransferase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.1312561Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also transfers phenylalanyl groups. Requires a univalent cation. Peptides and proteins containing an N-terminal arginine, lysine or histidine residue can act as acceptors.

Citations: [Soffer73, Leibowitz69, Leibowitz70]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03813

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P73571


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Leibowitz69: Leibowitz MJ, Soffer RL (1969). "A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins." Biochem Biophys Res Commun 36(1);47-53. PMID: 4894363

Leibowitz70: Leibowitz MJ, Soffer RL (1970). "Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli." J Biol Chem 245(8);2066-73. PMID: 4909560

Soffer73: Soffer RL (1973). "Peptide acceptors in the leucine, phenylalanine transfer reaction." J Biol Chem 248(24);8424-8. PMID: 4587124

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Thu Apr 28, 2016, BIOCYC11A.