|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Homo sapiens:||mitochondrial hydroxymethylglutaryl-CoA lyase: HMGCL|
|Pseudomonas aeruginosa PAO1:||hydroxymethylglutaryl-CoA lyase: liuE|
|Pseudomonas mevalonii:||hydroxymethylglutaryl-CoA lyase: mvaB|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: hydroxymethylglutaryl-CoA lyase
Enzyme Commission Synonyms: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
Standard Gibbs Free Energy (ΔrG'°): -1.2635498 kcal/mol [Latendresse13]
Bachhawat55: Bachhawat, B.K., Robinson, W.G., Coon, M.J. (1955). "The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A." J Biol Chem 216(2);727-36. PMID: 13271348
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