MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
hydroxymethylglutaryl-CoA lyase Inferred from experiment : liuE ( Pseudomonas aeruginosa PAO1 )
mitochondrial hydroxymethylglutaryl-CoA lyase Inferred from experiment : HMGCL ( Homo sapiens )
hydroxymethylglutaryl-CoA lyase Inferred from experiment : mvaB ( Pseudomonas mevalonii )

In Pathway: ketogenesis , L-leucine degradation I , mevalonate degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydroxymethylglutaryl-CoA lyase

Enzyme Commission Synonyms: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.2635498 Inferred by computational analysis [Latendresse13]

Citations: [Bachhawat55]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01360 , Rhea:24404

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P35914 , UniProt:RELATED-TO:P35915 , UniProt:RELATED-TO:Q8L7K2


Bachhawat55: Bachhawat, B.K., Robinson, W.G., Coon, M.J. (1955). "The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A." J Biol Chem 216(2);727-36. PMID: 13271348

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Mar 31, 2015, biocyc13.