twitter

MetaCyc Reaction: 4.1.3.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.3.4

Enzymes and Genes:

Homo sapiens : mitochondrial hydroxymethylglutaryl-CoA lyase Inferred from experiment : HMGCL
Pseudomonas aeruginosa PAO1 : hydroxymethylglutaryl-CoA lyase Inferred from experiment : liuE
Pseudomonas mevalonii : hydroxymethylglutaryl-CoA lyase Inferred from experiment : mvaB

In Pathway: ketogenesis , L-leucine degradation I , mevalonate degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydroxymethylglutaryl-CoA lyase

Enzyme Commission Synonyms: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.2635498 Inferred by computational analysis [Latendresse13]

Citations: [Bachhawat55]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01360 , Rhea:24404

Relationship Links: BRENDA:EC:4.1.3.4 , ENZYME:EC:4.1.3.4 , IUBMB-ExplorEnz:EC:4.1.3.4 , UniProt:RELATED-TO:P35914 , UniProt:RELATED-TO:P35915 , UniProt:RELATED-TO:Q8L7K2


References

Bachhawat55: Bachhawat, B.K., Robinson, W.G., Coon, M.J. (1955). "The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A." J Biol Chem 216(2);727-36. PMID: 13271348

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu May 28, 2015, BIOCYC13A.