|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
hydroxymethylglutaryl-CoA lyase : liuE ( Pseudomonas aeruginosa PAO1 )
mitochondrial hydroxymethylglutaryl-CoA lyase : HMGCL ( Homo sapiens )
hydroxymethylglutaryl-CoA lyase : mvaB ( Pseudomonas mevalonii )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: hydroxymethylglutaryl-CoA lyase
Enzyme Commission Synonyms: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.2635498 [Latendresse13]
Bachhawat55: Bachhawat, B.K., Robinson, W.G., Coon, M.J. (1955). "The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A." J Biol Chem 216(2);727-36. PMID: 13271348
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