MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Homo sapiens: mitochondrial hydroxymethylglutaryl-CoA lyaseInferred from experiment: HMGCL
Pseudomonas aeruginosa PAO1: hydroxymethylglutaryl-CoA lyaseInferred from experiment: liuE
Pseudomonas mevalonii: hydroxymethylglutaryl-CoA lyaseInferred from experiment: mvaB

In Pathway: ketogenesis, L-leucine degradation I, mevalonate degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: hydroxymethylglutaryl-CoA lyase

Enzyme Commission Synonyms: hydroxymethylglutaryl coenzyme A-cleaving enzyme, hydroxymethylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl coenzyme A lyase, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl-CoA lyase, (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase

Standard Gibbs Free Energy (ΔrG): -1.2635498 kcal/molInferred by computational analysis [Latendresse13]

Citations: [Bachhawat55]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Unification Links: KEGG:R01360, Rhea:24404

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P35914, UniProt:RELATED-TO:P35915, UniProt:RELATED-TO:Q8L7K2


Bachhawat55: Bachhawat, B.K., Robinson, W.G., Coon, M.J. (1955). "The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme A to acetoacetate and acetyl coenzyme A." J Biol Chem 216(2);727-36. PMID: 13271348

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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