Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.5.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.4.3

Enzymes and Genes:
guanine deaminase Inferred from experiment : guaD ( Escherichia coli K-12 substr. MG1655 )
guanine deaminase Inferred from experiment : DhpD ( Drosophila melanogaster )
guanine deaminase Inferred from experiment : GDA ( Homo sapiens )
guanine deaminase Inferred from experiment ( Clostridium cylindrosporum )
guanine deaminase Inferred from experiment ( Camellia sinensis )
guanine deaminase ( Halobacterium salinarum )

In Pathway: guanosine nucleotides degradation II , guanosine nucleotides degradation III , purine nucleobases degradation I (anaerobic) , purine nucleobases degradation II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: guanine deaminase

Enzyme Commission Synonyms: guanase, guanine aminase, GAH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.1229954 Inferred by computational analysis [Latendresse13]

Citations: [Rabinowitz56b, Hitchings44]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01676 , Rhea:14665

Relationship Links: BRENDA:EC:3.5.4.3 , ENZYME:EC:3.5.4.3 , IUBMB-ExplorEnz:EC:3.5.4.3


References

Hitchings44: Hitchings GH, Falco EA (1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase." Proc Natl Acad Sci U S A 30(10);294-7. PMID: 16578130

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rabinowitz56b: Rabinowitz, JC, Barker, HA (1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations." J Biol Chem 218(1);161-73. PMID: 13278325


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc12.