MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Crithidia fasciculata: glutathionylspermidine amidaseInferred from experiment: gspS
glutathionylspermidine amidase: TryS
Escherichia coli K-12 substr. MG1655: fused glutathionylspermidine amidase / glutathionylspermidine synthetaseInferred from experiment: gss

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutathionylspermidine amidase

Enzyme Commission Synonyms: glutathionylspermidine amidohydrolase (spermidine-forming)

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -2.3354187Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Transforms glutathionylspermidine into glutathione and spermidine. The enzyme from Escherichia coli is bifunctional and also catalyzes the reaction of EC, resulting in a net hydrolysis of ATP.

Citations: [Bollinger95]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01918, Rhea:17173

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Bollinger95: Bollinger JM, Kwon DS, Huisman GW, Kolter R, Walsh CT (1995). "Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase." J Biol Chem 1995;270(23);14031-41. PMID: 7775463

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13A.