MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
fused glutathionylspermidine amidase / glutathionylspermidine synthetase Inferred from experiment : gss ( Escherichia coli K-12 substr. MG1655 )
glutathionylspermidine amidase : TryS ( Crithidia fasciculata )
glutathionylspermidine amidase Inferred from experiment : gspS ( Crithidia fasciculata )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutathionylspermidine amidase

Enzyme Commission Synonyms: glutathionylspermidine amidohydrolase (spermidine-forming)

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -2.3354187 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Transforms glutathionylspermidine into glutathione and spermidine. The enzyme from Escherichia coli is bifunctional and also catalyzes the reaction of EC, resulting in a net hydrolysis of ATP.

Citations: [Bollinger95]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01918 , Rhea:17173

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Bollinger95: Bollinger JM, Kwon DS, Huisman GW, Kolter R, Walsh CT (1995). "Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase." J Biol Chem 1995;270(23);14031-41. PMID: 7775463

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Mar 27, 2015, BIOCYC14A.