MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: glycosylceramidase

Enzyme Commission Synonyms: phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, phloridzin glucosidase

Taxonomic Range: Metazoa

Enzyme Commission Summary:
Broad specificity [cf. EC (glucosylceramidase) and EC (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC lactase.

Citations: [Malathi69, LorenzMeyer72, Leese73 ]

Unification Links: KEGG:R01501

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P09848, UniProt:RELATED-TO:P09849, UniProt:RELATED-TO:Q02401, UniProt:RELATED-TO:Q29518, UniProt:RELATED-TO:Q29519, UniProt:RELATED-TO:Q29521, UniProt:RELATED-TO:Q29522


Leese73: Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase." J Biol Chem 248(23);8170-3. PMID: 4752949

LorenzMeyer72: Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase." Eur J Clin Invest 2(5);326-31. PMID: 5082068

Malathi69: Malathi P, Crane RK (1969). "Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane." Biochim Biophys Acta 173(2);245-56. PMID: 5774775

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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