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MetaCyc Reaction: 2.3.1.35

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.3.1.35

Enzymes and Genes:

Bacillus subtilis: ornithine acetyltransferaseInferred from experiment: argJ
Saccharomyces cerevisiae: acetylornithine acetyltransferase: ECM40

In Pathway: L-arginine biosynthesis II (acetyl cycle)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate N-acetyltransferase

Enzyme Commission Synonyms: ornithine transacetylase, α-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase, acetylglutamate synthetase, acetylglutamate-acetylornithine transacetylase, acetylglutamic synthetase, acetylglutamic-acetylornithine transacetylase, acetylornithinase, acetylornithine glutamate acetyltransferase, glutamate acetyltransferase, N-acetyl-L-glutamate synthetase, N-acetylglutamate synthase, N-acetylglutamate synthetase, ornithine acetyltransferase, 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase

Standard Gibbs Free Energy (ΔrG): -1.2482033 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.

Citations: [Staub66]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Unification Links: KEGG:R02282, Rhea:15349

Relationship Links: BRENDA:EC:2.3.1.35, ENZYME:EC:2.3.1.35, IUBMB-ExplorEnz:EC:2.3.1.35, UniProt:RELATED-TO:P38434, UniProt:RELATED-TO:P74122, UniProt:RELATED-TO:Q04728, UniProt:RELATED-TO:Q07908, UniProt:RELATED-TO:Q57645


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Staub66: Staub M, Denes G (1966). "Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. I. Purification and properties of ornithine acetyltransferase." Biochim Biophys Acta 128(1);82-91. PMID: 5972370


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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