Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.35

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.35

Enzymes and Genes:
acetylornithine acetyltransferase : ECM40 ( Saccharomyces cerevisiae )
ornithine acetyltransferase Inferred from experiment : argJ ( Bacillus subtilis )

In Pathway: arginine biosynthesis II (acetyl cycle)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate N-acetyltransferase

Enzyme Commission Synonyms: ornithine transacetylase, α-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase, acetylglutamate synθse, acetylglutamate-acetylornithine transacetylase, acetylglutamic synθse, acetylglutamic-acetylornithine transacetylase, acetylornithinase, acetylornithine glutamate acetyltransferase, glutamate acetyltransferase, N-acetyl-L-glutamate synθse, N-acetylglutamate synthase, N-acetylglutamate synθse, ornithine acetyltransferase, 2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.2482033 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also has some hydrolytic activity on acetyl-L-ornithine, but the rate is 1% of that of transferase activity.

Citations: [Staub66]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02282 , Rhea:15349

Relationship Links: BRENDA:EC:2.3.1.35 , ENZYME:EC:2.3.1.35 , IUBMB-ExplorEnz:EC:2.3.1.35 , UniProt:RELATED-TO:P38434 , UniProt:RELATED-TO:P74122 , UniProt:RELATED-TO:Q04728 , UniProt:RELATED-TO:Q07908 , UniProt:RELATED-TO:Q57645


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Staub66: Staub M, Denes G (1966). "Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. I. Purification and properties of ornithine acetyltransferase." Biochim Biophys Acta 128(1);82-91. PMID: 5972370


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc12.