Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.70

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.70

Enzymes and Genes:
glutaryl-CoA dehydrogenase Inferred from experiment : gcdH ( Pseudomonas Sp. K172 )
glutaconyl-CoA decarboxylase Inferred from experiment : gcdA , gcdB , gcdC , gcdD ( Acidaminococcus fermentans )

Sub-reaction of:
1.3.8.6: glutaryl-CoA + an oxidized electron-transfer flavoprotein = crotonyl-CoA + CO2 + a reduced electron-transfer flavoprotein

In Pathway: glutamate degradation V (via hydroxyglutarate) , glutaryl-CoA degradation , crotonate fermentation (to acetate and cyclohexane carboxylate)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutaconyl-CoA decarboxylase

Enzyme Commission Synonyms: glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, 4-carboxybut-2-enoyl-CoA carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.779419 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.

Citations: [Buckel01, Buckel83]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03028 , Rhea:23972

Relationship Links: BRENDA:EC:4.1.1.70 , ENZYME:EC:4.1.1.70 , IUBMB-ExplorEnz:EC:4.1.1.70


References

Buckel01: Buckel W (2001). "Sodium ion-translocating decarboxylases." Biochim Biophys Acta 1505(1);15-27. PMID: 11248185

Buckel83: Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria." Eur J Biochem 1983;136(2);427-34. PMID: 6628393

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 28, 2014, biocyc13.