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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Acidaminococcus fermentans: glutaconyl-CoA decarboxylaseInferred from experiment: gcdA, gcdB, gcdC, gcdD
Pseudomonas Sp. K172: glutaryl-CoA dehydrogenaseInferred from experiment: gcdH

Sub-reaction of: glutaryl-CoA + an oxidized electron-transfer flavoprotein + 2 H+ = crotonyl-CoA + CO2 + a reduced electron-transfer flavoprotein

In Pathway: glutaryl-CoA degradation, crotonate fermentation (to acetate and cyclohexane carboxylate), L-glutamate degradation V (via hydroxyglutarate)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutaconyl-CoA decarboxylase

Enzyme Commission Synonyms: glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, 4-carboxybut-2-enoyl-CoA carboxy-lyase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -1.779419Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.

Citations: [Buckel01, Buckel83]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03028, Rhea:23972

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Buckel01: Buckel W (2001). "Sodium ion-translocating decarboxylases." Biochim Biophys Acta 1505(1);15-27. PMID: 11248185

Buckel83: Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria." Eur J Biochem 1983;136(2);427-34. PMID: 6628393

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun May 1, 2016, BIOCYC11A.