|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 22.214.171.124
Enzymes and Genes:
|Acidaminococcus fermentans:||glutaconyl-CoA decarboxylase: gcdA, gcdB, gcdC, gcdD|
|Pseudomonas Sp. K172:||glutaryl-CoA dehydrogenase: gcdH|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glutaconyl-CoA decarboxylase
Enzyme Commission Synonyms: glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, 4-carboxybut-2-enoyl-CoA carboxy-lyase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.779419 [Latendresse13]
Enzyme Commission Summary:
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
Buckel83: Buckel W, Semmler R (1983). "Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria." Eur J Biochem 1983;136(2);427-34. PMID: 6628393
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493